Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1D | P25100 | 1/20 | 0.57 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.57 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.57 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.44 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.44 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.44 |
| ▸ | CD44 | P16070 | 2/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 5/20 | 0.34 |
| ▸ | DRD2 | P14416 | 4/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | PRCP | P42785 | 1/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2321445 | 0.78 | ADRA1D (0.81) | ADRA1DADRA1AADRA1BADRA2AADRA2B | |
| SCHEMBL23714130 | 0.74 | ADRA1D (0.62) | ADRA1DADRA1AADRA1BADRA2AADRA2B | |
| SCHEMBL9537435 | 0.73 | SIGMAR1 (0.46) | ADRA2AADRA2BADRA2CCD44SIGMAR1 | |
| Azapetine SCHEMBL29763084 | 0.73 | ADRA1D (1.00) | ADRA1DADRA1AADRA1BADRA2AADRA2B | |
| Azapetine SCHEMBL456796 | 0.73 | ADRA1D (1.00) | ADRA1DADRA1AADRA1BADRA2AADRA2B | |
| Hydrochloric Acid SCHEMBL8330798 | 0.72 | SIGMAR1 (0.44) | ADRA2AADRA2BADRA2CCD44SIGMAR1 | |
| Azapetine SCHEMBL6763929 | 0.72 | ADRA1D (0.96) | ADRA1DADRA1AADRA1BADRA2AADRA2B | |
| SCHEMBL10995993 | 0.70 | ADRA2A (0.55) | ADRA1DADRA1AADRA1BADRA2AADRA2B | |
| SCHEMBL4277150 | 0.69 | ADRA1D (0.61) | ADRA1DADRA1AADRA1BADRA2AADRA2B | |
| SCHEMBL11827897 | 0.69 | ADRA1D (0.56) | ADRA1DADRA1AADRA1BADRA2AADRA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2029535-A1 | ISOINDOLE DERIVATIVES USEFUL FOR TREATING PAIN, GASTROINTESTINAL DISEASES AND CANCER | AstraZeneca AB (SE) | 2009-03-04 | — | — | EP | disclosed |
| WO-2007139464-A1 | ISOINDOLE DERIVATIVES USEFUL FOR TREATING PAIN, GASTROINTESTINAL DISEASES AND CANCER | ASTRAZENECA AB (SE) | 2007-12-06 | — | — | WO | disclosed |