Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 2/20 | 0.45 |
| ▸ | EGFR | P00533 | 2/20 | 0.45 |
| ▸ | CCNT1 | O60563 | 3/20 | 0.44 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.44 |
| ▸ | CDK2 | P24941 | 3/20 | 0.44 |
| ▸ | CDK9 | P50750 | 3/20 | 0.44 |
| ▸ | CDK1 | P06493 | 1/20 | 0.44 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.44 |
| ▸ | CDK7 | P50613 | 1/20 | 0.44 |
| ▸ | CCNH | P51946 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | RORC | P51449 | 2/20 | 0.42 |
| ▸ | PHGDH | O43175 | 1/20 | 0.42 |
| ▸ | SETD2 | Q9BYW2 | 1/20 | 0.41 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | DHFR | P00374 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2655693 | 0.88 | GAA (0.52) | EGFRCCNT1CCNA2CDK2CDK9 | |
| SCHEMBL2654961 | 0.85 | AKR1C3 (0.47) | SCN9AEGFRRORCENPP2MAPT | |
| SCHEMBL2656292 | 0.85 | LMNA (0.52) | CCNT1CCNA2CDK2CDK9CDK1 | |
| SCHEMBL2653555 | 0.82 | NPC1 (0.49) | CCNT1CCNA2CDK2CDK9CDK1 | |
| SCHEMBL2655735 | 0.81 | MAPT (0.48) | EGFRCCNT1CCNA2CDK2CDK9 | |
| SCHEMBL2654981 | 0.78 | SMN1; SMN2 (0.51) | EGFRCCNT1CCNA2CDK2CDK9 | |
| SCHEMBL2655224 | 0.78 | CCNT1 (0.45) | EGFRCCNT1CCNA2CDK2CDK9 | |
| SCHEMBL2653592 | 0.77 | MAPT (0.43) | EGFRCCNT1CCNA2CDK2CDK9 | |
| SCHEMBL2654719 | 0.77 | CCNT1 (0.42) | EGFRCCNT1CCNA2CDK2CDK9 | |
| SCHEMBL4202254 | 0.77 | KDM4E (0.42) | EGFRCCNT1CCNA2CDK2CDK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090062304-A1 | Benzimidazole derivatives and their use for modulating the gaba-alpha receptor complex | NEUROSEARCH A/S (DK) | 2009-03-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090062304-A1 | Benzimidazole derivatives and their use for modulating the gaba-alpha receptor complex | GABRB1, GABRB2, GABRB3 | SCN9A 1783/4885EGFR 2576/4885CCNT1 4531/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.