Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.51 |
| ▸ | RXFP1 | Q9HBX9 | 4/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | PPARG | P37231 | 1/20 | 0.48 |
| ▸ | NR2E3 | Q9Y5X4 | 1/20 | 0.48 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4203809 | 0.87 | MEN1 (0.61) | SMN1; SMN2KMT2AMEN1RCE1RXFP1 | |
| SCHEMBL4195433 | 0.79 | ADORA3 (0.44) | SMN1; SMN2RXFP1POLBLMNATP53 | |
| SCHEMBL4201351 | 0.77 | TP53 (0.42) | KMT2AMEN1RXFP1TP53MAPT | |
| SCHEMBL823459 | 0.71 | MEN1 (0.58) | SMN1; SMN2KMT2AMEN1TP53KDM4E | |
| SCHEMBL18196228 | 0.70 | KCNE1 (0.53) | SMN1; SMN2KMT2AMEN1RCE1RXFP1 | |
| SCHEMBL6017632 | 0.69 | KCNE1 (0.54) | SMN1; SMN2KMT2AMEN1RCE1RXFP1 | |
| SCHEMBL15336453 | 0.68 | LIPG (0.47) | SMN1; SMN2KMT2AMEN1RXFP1POLB | |
| SCHEMBL28434603 | 0.68 | MAPK14 (0.45) | SMN1; SMN2KMT2AMEN1RXFP1POLB | |
| SCHEMBL4203022 | 0.67 | SMN1; SMN2 (0.53) | SMN1; SMN2KMT2AMEN1POLBLMNA | |
| SCHEMBL6018704 | 0.67 | KCNE1 (0.56) | SMN1; SMN2KMT2AMEN1RCE1RXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7476666-B2 | HIV integrase inhibitors | MERCK & CO., INC. (US) | 2009-01-13 | — | — | US | disclosed |
| US-20080015187-A1 | Hiv Integrase Inhibitors | MERCK SHARP & DOHME CORP. | 2008-01-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080015187-A1 | Hiv Integrase Inhibitors | REV1, ZC3HAV1, PNP | SMN1; SMN2 4093/4885KMT2A 2181/4885MEN1 4287/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.