Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Flucytosine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALB | P02768 | 1/20 | 0.32 |
| ▸ | PRKAG1 | P54619 | 2/20 | 0.31 |
| ▸ | PRKAA2 | P54646 | 2/20 | 0.31 |
| ▸ | PRKAB1 | Q9Y478 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 4/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.31 |
| ▸ | DNMT1 | P26358 | 2/20 | 0.31 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.31 |
| ▸ | MTOR | P42345 | 2/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.30 |
| ▸ | THRB | P10828 | 1/20 | 0.30 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.30 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.30 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | GMNN | O75496 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.30 |
| ▸ | THPO | P40225 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4199979 | 0.86 | PNP (0.32) | LMNASMN1; SMN2DNMT1ADRB1MTOR | |
| SCHEMBL4208334 | 0.81 | ADORA2A (0.31) | — | |
| SCHEMBL10340290 | 0.78 | DPP4 (0.31) | PRKAG1PRKAA2PRKAB1LMNASMN1; SMN2 | |
| Cytosine SCHEMBL4198774 | 0.78 | LMNA (0.38) | ALBLMNASMN1; SMN2DNMT1ADRB1 | |
| Fluorouracil SCHEMBL4289411 | 0.76 | LMNA (0.50) | PRKAG1PRKAA2PRKAB1LMNASMN1; SMN2 | |
| SCHEMBL4198780 | 0.74 | — | — | |
| Flucytosine SCHEMBL24063 | 0.73 | — | — | |
| Flucytosine SCHEMBL8160959 | 0.73 | ALDH1A1 (0.37) | LMNASMN1; SMN2MTORALDH1A1THPO | |
| SCHEMBL10422311 | 0.72 | PNP (0.31) | — | |
| Flucytosine SCHEMBL3867430 | 0.72 | ALDH1A1 (0.33) | LMNASMN1; SMN2MTORALDH1A1THPO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7608402-B2 | DNA methylation specific signal amplification | LI WEIWEI | 2009-10-27 | — | — | US | disclosed |
| US-20090181373-A1 | DNA methylation specific signal amplification | LI WEIWEI | 2009-07-16 | — | — | US | disclosed |