Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | JUN | P05412 | 1/20 | 0.51 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.51 |
| ▸ | TBXAS1 | P24557 | 2/20 | 0.51 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.49 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.49 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.49 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4201926 | 1.00 | MAPT (0.51) | MAPTRAB9AKDM4ENPC1JUN | |
| SCHEMBL30396999 | 1.00 | MAPT (0.51) | MAPTRAB9AKDM4ENPC1JUN | |
| SCHEMBL14423635 | 0.82 | TBXAS1 (0.70) | MAPTRAB9AKDM4ENPC1JUN | |
| SCHEMBL17787984 | 0.81 | MAPT (0.62) | MAPTRAB9AKDM4ENPC1JUN | |
| SCHEMBL9488251 | 0.81 | MAPT (0.61) | MAPTRAB9AKDM4ENPC1JUN | |
| SCHEMBL10891882 | 0.81 | PAM (0.61) | MAPTRAB9AKDM4ENPC1KMT2A | |
| SCHEMBL10891880 | 0.81 | PAM (0.61) | MAPTRAB9AKDM4ENPC1KMT2A | |
| SCHEMBL10397776 | 0.81 | CHRNB2 (0.56) | MAPTRAB9AKDM4ENPC1JUN | |
| SCHEMBL9519242 | 0.81 | CHRNB2 (0.56) | MAPTRAB9AKDM4ENPC1JUN | |
| SCHEMBL9523207 | 0.81 | CHRNB2 (0.56) | MAPTRAB9AKDM4ENPC1JUN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9511060-B2 | Non-flushing niacin analogues, and methods of use thereof | TRUSTEES OF TUFTS COLLEGE (US) | 2016-12-06 | — | — | US | disclosed |
| US-20160151343-A1 | NON-FLUSHING NIACIN ANALOGUES, AND METHODS OF USE THEREOF | TRUSTEES OF TUFTS COLLEGE | 2016-06-02 | — | — | US | disclosed |
| US-9193708-B2 | Non-flushing niacin analogues, and methods of use thereof | TRUSTEES OF TUFTS COLLEGE (US) | 2015-11-24 | — | — | US | disclosed |
| US-20150099787-A1 | Non-Flushing Niacin Analogues, and Methods of Use Thereof | TRUSTEES OF TUFTS COLLEGE (US) | 2015-04-09 | — | — | US | disclosed |
| US-8889720-B2 | Non-flushing niacin analogues, and methods of use thereof | TRUSTEES OF TUFTS COLLEGE (US) | 2014-11-18 | — | — | US | disclosed |
| EP-2054386-B1 | NON-FLUSHING NIACIN ANALOGUES, AND METHODS OF USE THEREOF | TUFTS COLLEGE (US) | 2014-10-08 | — | — | EP | disclosed |
| US-20130217714-A1 | Non-Flushing Niacin Analogues, and Methods of Use Thereof | TRUSTEES OF TUFTS COLLEGE (US) | 2013-08-22 | — | — | US | disclosed |
| CN-101522623-B | Non-flushing nicotinic acid analogs and methods of use thereof | TUFTS COLLEGE | 2013-06-12 | — | — | CN | disclosed |
| US-8377971-B2 | Non-flushing niacin analogues, and methods of use thereof | TRUSTEES OF TUFTS COLLEGE (US) | 2013-02-19 | — | — | US | disclosed |
| US-20090312355-A1 | Non-Flushing Niacin Analogues, and Methods of Use Thereof | TRUSTEES OF TUFTS COLLEGE (US) | 2009-12-17 | — | — | US | disclosed |
| CN-101522623-A | Non-flushing nicotinic acid analogs and methods of use thereof | TUFTS COLLEGE (US) | 2009-09-02 | — | — | CN | disclosed |
| EP-2054386-A2 | NON-FLUSHING NIACIN ANALOGUES, AND METHODS OF USE THEREOF | TRUSTEES OF TUFTS COLLEGE (US) | 2009-05-06 | — | — | EP | disclosed |
| WO-2008016968-A2 | NON-FLUSHING NIACIN ANALOGUES, AND METHODS OF USE THEREOF | TRUSTEES OF TUFTS COLLEGE (US) | 2008-02-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130217714-A1 | Non-Flushing Niacin Analogues, and Methods of Use Thereof | SLC33A1, CHLSN, APOB | MAPT 1932/4885RAB9A 4152/4885KDM4E 4391/4885 |
| US-20090312355-A1 | Non-Flushing Niacin Analogues, and Methods of Use Thereof | SLC33A1, CHLSN, APOB | MAPT 1937/4885RAB9A 4145/4885KDM4E 4388/4885 |
| US-20160151343-A1 | NON-FLUSHING NIACIN ANALOGUES, AND METHODS OF USE THEREOF | SLC33A1, CHLSN, APOB | MAPT 1932/4885RAB9A 4152/4885KDM4E 4391/4885 |
| US-20150099787-A1 | Non-Flushing Niacin Analogues, and Methods of Use Thereof | SLC33A1, CHLSN, APOB | MAPT 1883/4885RAB9A 4123/4885KDM4E 4393/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.