Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.61 |
| ▸ | RAB9A | P51151 | 2/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.61 |
| ▸ | NPC1 | O15118 | 1/20 | 0.61 |
| ▸ | JUN | P05412 | 1/20 | 0.61 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.61 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.61 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.59 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.53 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.53 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.53 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.53 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.53 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.53 |
| ▸ | PFKFB3 | Q16875 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4592716 | 0.89 | TBXAS1 (0.59) | MAPTRAB9AKDM4ENPC1JUN | |
| SCHEMBL868080 | 0.88 | TBXAS1 (0.66) | MAPTRAB9AKDM4ENPC1JUN | |
| SCHEMBL868079 | 0.88 | TBXAS1 (0.66) | MAPTRAB9AKDM4ENPC1JUN | |
| SCHEMBL30227267 | 0.88 | TBXAS1 (0.66) | MAPTRAB9AKDM4ENPC1JUN | |
| SCHEMBL23992178 | 0.86 | TBXAS1 (0.60) | MAPTRAB9AKDM4ENPC1JUN | |
| SCHEMBL17787984 | 0.86 | MAPT (0.62) | MAPTRAB9AKDM4ENPC1JUN | |
| SCHEMBL4201930 | 0.81 | MAPT (0.51) | MAPTRAB9AKDM4ENPC1JUN | |
| SCHEMBL30396999 | 0.81 | MAPT (0.51) | MAPTRAB9AKDM4ENPC1JUN | |
| SCHEMBL4201926 | 0.81 | MAPT (0.51) | MAPTRAB9AKDM4ENPC1JUN | |
| SCHEMBL6132907 | 0.79 | CYP11B2 (0.59) | MAPTRAB9AKDM4ENPC1JUN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0302227-B1 | 5-HALO-6-AMINO-NICOTINIC ACID HALIDES, THEIR PREPARATION AND THEIR USE | BAYER AG (DE) | 1993-01-13 | — | — | EP | disclosed |
| US-4895950-A | 5-halogeno-6-amino-nicotinic acid halides | BAYER AKTIENGESELLSCHAFT (DE) | 1990-01-23 | — | — | US | disclosed |
| EP-0302227-A2 | 5-Halo-6-amino-nicotinic acid halides, their preparation and their use | BAYER AG (DE) | 1989-02-08 | — | — | EP | disclosed |
| EP-0302227-A2 | 5-Halo-6-amino-nicotinic acid halides, their preparation and their use | BAYER AG (DE) | 1989-02-08 | — | — | EP | disclosed |