SCHEMBL420577

SCHEMBL420577

CCOC(=O)C1CCC=CO1

nearest known ligand 0.41

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 6/20 0.40
USP2 O75604 1/20 0.40
ALOX15 P16050 1/20 0.40
TDP1 Q9NUW8 1/20 0.40
PPM1B O75688 1/20 0.39
PTPN1 P18031 1/20 0.39
PPP1CC P36873 1/20 0.39
CYP4F2 P78329 1/20 0.38
CYP4A11 Q02928 1/20 0.38
MEN1 O00255 2/20 0.35
KMT2A Q03164 2/20 0.35
POLB P06746 1/20 0.35
MAPT P10636 3/20 0.35
TSHR P16473 1/20 0.35
KDM4E B2RXH2 1/20 0.34
GAA P10253 1/20 0.34
HPGD P15428 1/20 0.34
HSD17B10 Q99714 1/20 0.34
SOAT1 P35610 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5186955 0.82 ALDH1A1 (0.38) ALDH1A1TDP1PPM1BPTPN1PPP1CC
SCHEMBL9253272 0.80 PPM1B (0.34) ALDH1A1PPM1BPTPN1PPP1CCMAPT
SCHEMBL10404054 0.80
SCHEMBL4304520 0.80 TP53 (0.37)
SCHEMBL9808616 0.78
SCHEMBL13072517 0.77
SCHEMBL9253268 0.77
SCHEMBL10333430 0.75 NPC1 (0.31) MAPT
SCHEMBL9564946 0.74 LMNA (0.52) ALDH1A1KMT2APOLB
SCHEMBL7921737 0.74 PPM1B (0.40) ALDH1A1PPM1BPTPN1PPP1CCCYP4F2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0514515-A1 ANTHRACYCLINE-CONJUGATES. ERBA CARLO SPA (IT) 1992-11-25 EP claimed
WO-1992010212-A1 ANTHRACYCLINE-CONJUGATES FARMITALIA CARLO ERBA SRL (IT) 1992-06-25 WO claimed
US-12054484-B2 Substituted tetrahydropyrans as CCR2 modulators CHEMOCENTRYX, INC. (US) 2024-08-06 US disclosed
US-20220153733-A1 SUBSTITUTED TETRAHYDROPYRANS AS CCR2 MODULATORS CHEMOCENTRYX, INC. 2022-05-19 US disclosed
US-20220153733-A1 SUBSTITUTED TETRAHYDROPYRANS AS CCR2 MODULATORS CHEMOCENTRYX, INC. 2022-05-19 US disclosed
EP-3297438-B1 CCR2 MODULATORS CHEMOCENTRYX INC (US) 2021-10-20 EP disclosed
CN-108135168-B CCR2 modulators 凯莫森特里克斯股份有限公司 2021-07-20 CN disclosed
US-20200121688-A1 SUBSTITUTED TETRAHYDROPYRANS AS CCR2 MODULATORS CHEMOCENTRYX, INC. 2020-04-23 US disclosed
US-20200121688-A1 SUBSTITUTED TETRAHYDROPYRANS AS CCR2 MODULATORS CHEMOCENTRYX, INC. 2020-04-23 US disclosed
US-10464934-B2 Substituted tetrahydropyrans as CCR2 modulators CHEMOCENTRYX, INC. (US) 2019-11-05 US disclosed
US-20180086756-A1 SUBSTITUTED TETRAHYDROPYRANS AS CCR2 MODULATORS CHEMOCENTRYX, INC. 2018-03-29 US disclosed
WO-2016187393-A1 CCR2 MODULATORS CHEMOCENTRYX, INC. (US) 2016-11-24 WO disclosed
WO-2016187393-A1 CCR2 MODULATORS CHEMOCENTRYX, INC. (US) 2016-11-24 WO disclosed
US-20160340356-A1 CCR2 MODULATORS CHEMOCENTRYX, INC. 2016-11-24 US disclosed
US-20120022045-A1 BRIDGED COMPOUNDS AS HIV INTEGRASE INHIBITORS VENKATRAMAN SHANKAR (US) 2012-01-26 US disclosed
US-5776458-A ANTITUMOR AGENTS PHARMACIA & UPJOHN S.P.A. (IT) 1998-07-07 US disclosed
EP-0514515-B1 ANTHRACYCLINE-CONJUGATES PHARMACIA & UPJOHN SPA (IT) 1997-04-16 EP disclosed
EP-0514515-A1 ANTHRACYCLINE-CONJUGATES. ERBA CARLO SPA (IT) 1992-11-25 EP disclosed
WO-1992010212-A1 ANTHRACYCLINE-CONJUGATES FARMITALIA CARLO ERBA SRL (IT) 1992-06-25 WO disclosed
US-4677190-A Synthesis and ring-opening polymerization of bicyclic lactones containing a tetrahydropyran ring UNIVERSITY PATENTS, INC. (US) 1987-06-30 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10464934-B2 Substituted tetrahydropyrans as CCR2 modulators CCR2, CCR1, CCR5 ALDH1A1 1316/4885USP2 4725/4885ALOX15 1844/4885
US-20120022045-A1 BRIDGED COMPOUNDS AS HIV INTEGRASE INHIBITORS CCND3, CDK3, CDK2 ALDH1A1 2994/4885USP2 3207/4885ALOX15 4800/4885
US-20180086756-A1 SUBSTITUTED TETRAHYDROPYRANS AS CCR2 MODULATORS CCR2, CCR1, CCR5 ALDH1A1 1316/4885USP2 4725/4885ALOX15 1844/4885
US-12054484-B2 Substituted tetrahydropyrans as CCR2 modulators CCR2, CCR1, CCR5 ALDH1A1 538/4885USP2 4484/4885ALOX15 1717/4885
US-20200121688-A1 SUBSTITUTED TETRAHYDROPYRANS AS CCR2 MODULATORS CCR2, CCR1, CCR5 ALDH1A1 1316/4885USP2 4725/4885ALOX15 1844/4885
US-20220153733-A1 SUBSTITUTED TETRAHYDROPYRANS AS CCR2 MODULATORS CCR2, CCR1, CCR5 ALDH1A1 520/4885USP2 4505/4885ALOX15 1670/4885
US-20160340356-A1 CCR2 MODULATORS CCR2, CCR1, CCR5 ALDH1A1 1533/4885USP2 4220/4885ALOX15 1171/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.