Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | GAA | P10253 | 5/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4217064 | 0.72 | FABP1 (0.42) | ALDH1A1SMN1; SMN2MAPK1MAPTGAA | |
| SCHEMBL4207423 | 0.71 | GAA (0.45) | ALDH1A1MAPK1MAPTGAAHSD17B10 | |
| SCHEMBL4208499 | 0.71 | GAA (0.47) | ALDH1A1MAPK1MAPTGAAPOLB | |
| SCHEMBL4203707 | 0.70 | ALDH1A1 (0.42) | ALDH1A1ALOX15SMN1; SMN2MAPK1MAPT | |
| SCHEMBL4212852 | 0.69 | FABP1 (0.45) | ALDH1A1MAPK1MAPTGAAHPGD | |
| SCHEMBL4208204 | 0.69 | ALDH1A1 (0.44) | ALDH1A1MAPK1MAPTGAAHTT | |
| SCHEMBL4220008 | 0.69 | ALDH1A1 (0.40) | ALDH1A1ALOX15MAPK1MAPTGAA | |
| SCHEMBL1381205 | 0.69 | ALOX15 (0.43) | ALDH1A1ALOX15MAPK1MAPTGAA | |
| SCHEMBL4209294 | 0.67 | QPCT (0.42) | ALDH1A1MAPK1MAPTGAAHTT | |
| SCHEMBL4037009 | 0.67 | ALDH1A1 (0.52) | ALDH1A1ALOX15SMN1; SMN2MAPK1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8404690-B2 | Piperazine-2-carboxamide derivatives | MERCK SERONO SA (CH) | 2013-03-26 | — | — | US | claimed |
| EP-1592389-B1 | PIPERAZINE-2-CARBOXAMIDE DERIVATIVES | SERONO LAB (CH) | 2009-04-22 | — | — | EP | claimed |