Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FABP1 | P07148 | 5/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.42 |
| ▸ | COMT | P21964 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | GFER | P55789 | 1/20 | 0.38 |
| ▸ | PKLR | P30613 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4212852 | 0.95 | FABP1 (0.45) | FABP1MAPK1GAAALDH1A1MAPT | |
| SCHEMBL4208204 | 0.91 | ALDH1A1 (0.44) | FABP1MAPK1GAAALDH1A1MAPT | |
| SCHEMBL4214876 | 0.90 | FABP1 (0.40) | FABP1MAPK1GAAALDH1A1MAPT | |
| SCHEMBL4208499 | 0.88 | GAA (0.47) | FABP1MAPK1GAAALDH1A1MAPT | |
| SCHEMBL4209294 | 0.85 | QPCT (0.42) | FABP1MAPK1GAAALDH1A1MAPT | |
| SCHEMBL4220008 | 0.82 | ALDH1A1 (0.40) | FABP1MAPK1GAAALDH1A1MAPT | |
| SCHEMBL4207423 | 0.74 | GAA (0.45) | FABP1MAPK1GAAALDH1A1MAPT | |
| SCHEMBL4207201 | 0.72 | ALDH1A1 (0.53) | MAPK1GAAALDH1A1MAPTHTT | |
| SCHEMBL4038524 | 0.70 | MMP2 (0.34) | — | |
| SCHEMBL4037792 | 0.70 | ALDH1A1 (0.37) | GAAALDH1A1SMN1; SMN2PKMTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8404690-B2 | Piperazine-2-carboxamide derivatives | MERCK SERONO SA (CH) | 2013-03-26 | — | — | US | claimed |
| EP-1592389-B1 | PIPERAZINE-2-CARBOXAMIDE DERIVATIVES | SERONO LAB (CH) | 2009-04-22 | — | — | EP | claimed |