Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A1 | P22736 | 1/20 | 0.58 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.58 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.56 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.56 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.56 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.56 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.56 |
| ▸ | MAOB | P27338 | 2/20 | 0.55 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.55 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.54 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 3/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4209193 | 1.00 | NR4A1 (0.58) | NR4A1NR4A2NR4A3SMN1; SMN2KDM4E | |
| SCHEMBL5706491 | 0.87 | NR4A1 (0.58) | NR4A1NR4A2NR4A3SMN1; SMN2KDM4E | |
| SCHEMBL17276674 | 0.86 | MAOB (0.58) | NR4A1NR4A2NR4A3SMN1; SMN2LMNA | |
| SCHEMBL7908828 | 0.84 | NR4A1 (0.55) | NR4A1NR4A2NR4A3SMN1; SMN2KDM4E | |
| SCHEMBL4216593 | 0.82 | SMN1; SMN2 (0.84) | SMN1; SMN2KDM4ERAB9ANPC1MAPT | |
| SCHEMBL4216595 | 0.82 | SMN1; SMN2 (0.84) | SMN1; SMN2KDM4ERAB9ANPC1MAPT | |
| SCHEMBL8407033 | 0.81 | MGLL (0.58) | SMN1; SMN2KDM4ELMNACYP1A2PTGS1 | |
| SCHEMBL257218 | 0.80 | CTSL (0.55) | SMN1; SMN2KDM4E | |
| SCHEMBL4586157 | 0.80 | CTSL (0.55) | SMN1; SMN2KDM4E | |
| SCHEMBL4586154 | 0.80 | CTSL (0.55) | SMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090131397-A1 | ESTROGEN MODULATORS | PFIZER INC. | 2009-05-21 | — | — | US | disclosed |
| US-7470715-B2 | Estrogen modulators | PFIZER INC. (US) | 2008-12-30 | — | — | US | disclosed |
| EP-1966170-A2 | ESTROGEN MODULATORS | Pfizer Products Inc. (US) | 2008-09-10 | — | — | EP | disclosed |
| WO-2007072164-A2 | ESTROGEN MODULATORS | PFIZER PRODUCTS INC. (US) | 2007-06-28 | — | — | WO | disclosed |
| US-20070149564-A1 | ESTROGEN MODULATORS | PFIZER INC. (US) | 2007-06-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090131397-A1 | ESTROGEN MODULATORS | ESR2, GPER1, ESR1 | NR4A1 68/4885NR4A2 50/4885NR4A3 32/4885 |
| US-20070149564-A1 | ESTROGEN MODULATORS | ESR2, GPER1, ESR1 | NR4A1 68/4885NR4A2 50/4885NR4A3 32/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.