SCHEMBL4586157

SCHEMBL4586157

ON=C(Cc1ccccc1)c1ccccc1

nearest known ligand 0.55

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
CTSL P07711 1/20 0.55
KDM4E B2RXH2 1/20 0.53
SMN1; SMN2 Q16637 1/20 0.53
CTBP2 P56545 1/20 0.50
XDH P47989 6/20 0.49
MGLL Q99685 3/20 0.47
TSHR P16473 1/20 0.47
ALOX12 P18054 1/20 0.47
ATM Q13315 1/20 0.45
CES2 O00748 1/20 0.44
CES1 P23141 1/20 0.44
AKR1B1 P15121 1/20 0.44
NLRP3 Q96P20 2/20 0.42
TLR4 O00206 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL257218 1.00 CTSL (0.55) CTSLKDM4ESMN1; SMN2CTBP2XDH
SCHEMBL4586154 1.00 CTSL (0.55) CTSLKDM4ESMN1; SMN2CTBP2XDH
SCHEMBL8407033 0.88 MGLL (0.58) CTSLKDM4ESMN1; SMN2CTBP2XDH
SCHEMBL28302059 0.88 LMNA (0.52) CTSLKDM4ESMN1; SMN2CTBP2XDH
SCHEMBL4586342 0.86 ALDH1A1 (0.51) CTSLKDM4ESMN1; SMN2CTBP2XDH
SCHEMBL9324776 0.86 KDM4E (0.46) CTSLKDM4ESMN1; SMN2CTBP2XDH
SCHEMBL9324768 0.86 KDM4E (0.46) CTSLKDM4ESMN1; SMN2CTBP2XDH
SCHEMBL9321485 0.86 GAA (0.50) CTSLKDM4ESMN1; SMN2CTBP2XDH
SCHEMBL4587535 0.86 SMN1; SMN2 (0.50) CTSLKDM4ESMN1; SMN2CTBP2XDH
SCHEMBL13853886 0.86 KDM4E (0.54) CTSLKDM4ESMN1; SMN2CTBP2XDH

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 154 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118638503-A Reusable polyurethane hot melt adhesive containing multiple dynamic covalent bond crosslinking and preparation method and application thereof 浙江禾欣科技有限公司 2024-09-13 CN claimed
CN-116334785-A Method for preparing covalent cross-linked fiber from covalent adaptive network 东华大学 2023-06-27 CN claimed
CN-112479997-B Synthetic method of 2, 3-diphenylquinoline 湖南工程学院 2022-02-08 CN claimed
CN-112830913-A Method for preparing 2, 5-furan diformylaldoxime 中国科学院宁波材料技术与工程研究所 2021-05-25 CN claimed
CN-103172583-A Parecoxib preparation method SHENZHEN JIFU PHARMACEUTICAL CO LTD 2013-06-26 CN claimed
CN-101412666-B Method for preparing carbonyl compound by catalytic oxidation of oxime UNIV SUN YAT SEN 2011-05-04 CN claimed
EP-1527165-A4 A RHODOCOCCUS GENE ENCODING ALDOXIME DEHYDRATASE DU PONT (US) 2006-06-07 EP claimed
EP-1527165-A2 A RHODOCOCCUS GENE ENCODING ALDOXIME DEHYDRATASE E.I. du Pont de Nemours and Company (US) 2005-05-04 EP claimed
EP-1438300-A1 METHOD FOR PREPARING BENZENESULFONYL COMPOUNDS Pharmacia Corporation (US) 2004-07-21 EP claimed
WO-2003078581-A2 A RHODOCOCCUS GENE ENCODING ALDOXIME DEHYDRATASE E.I. DU PONT DE NEMOURS AND COMPANY (US) 2003-09-25 WO claimed
US-20030105334-A1 Method for preparing benzenesulfonyl compounds LETENDRE LEO J (US) 2003-06-05 US claimed
WO-2003029230-A1 METHOD FOR PREPARING BENZENESULFONYL COMPOUNDS PHARMACIA CORPORATION (US) 2003-04-10 WO claimed
US-4327222-A REACTING AN ARYL SUBSTITUTED KETONE WITH HYDROXYLAMINE TO FORM OXIME, THEN CYCLIZATION WITH BUTYLLITHIUM CDC LIFE SCIENCES INC. (CA) 1982-04-27 US claimed
EP-0026928-A1 3,4-Diarylisoxazol-5-acetic acid compounds, process for preparing the same, and pharmaceuticals containing the same CDC Life Sciences Inc. (CA) 1981-04-15 EP claimed
JP-62270567-A None JP disclosed
CN-118638503-A Reusable polyurethane hot melt adhesive containing multiple dynamic covalent bond crosslinking and preparation method and application thereof 浙江禾欣科技有限公司 2024-09-13 CN disclosed
CN-115160962-B Anaerobic sealant and preparation method thereof 硕德半导体技术(苏州)有限公司 2024-01-26 CN disclosed
US-4194050-A HYDROGENATING OXIMES HAVING AN ALPHA-HYDROGEN USING A RUTHENIUM CATALYST AND A CARBOXYLIC ANHYDRIDE SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1980-03-18 US disclosed
US-4190656-A VIRICIDES, ANTITUMOR AGENTS TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1980-02-26 US disclosed
US-4137417-A Process for producing an enamide SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1979-01-30 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030105334-A1 Method for preparing benzenesulfonyl compounds TST, PTGS2, STS CTSL 2598/4885KDM4E 877/4885SMN1; SMN2 2104/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.