SCHEMBL4211086

SCHEMBL4211086

O=C(O)c1ccc(CCc2ccccc2)cc1Nc1cccc2cccnc12

nearest known ligand 0.51

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
▸ GLO1 Q04760 4/20 0.51
▸ MAPT P10636 3/20 0.49
▸ EGLN1 Q9GZT9 2/20 0.49
▸ PLEC Q15149 1/20 0.49
▸ KDR P35968 2/20 0.47
▸ MEN1 O00255 3/20 0.46
▸ KMT2A Q03164 3/20 0.46
▸ SMN1; SMN2 Q16637 2/20 0.46
▸ POLB P06746 1/20 0.45
▸ ALDH1A1 P00352 2/20 0.45
▸ LMNA P02545 1/20 0.45
▸ ALOX12 P18054 1/20 0.45
▸ HDAC6 Q9UBN7 2/20 0.45
▸ TDP1 Q9NUW8 2/20 0.45
▸ RECQL P46063 1/20 0.45
▸ BLM P54132 1/20 0.45
▸ KDM4E B2RXH2 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10505456 0.82 ALDH1A1 (0.60) MAPTPLECKDRMEN1KMT2A
SCHEMBL4215643 0.82 MAPT (0.52) MAPTPLECKDRMEN1KMT2A
SCHEMBL4210974 0.80 TRPV1 (0.56) MAPTSMN1; SMN2ALDH1A1KDM4E
SCHEMBL4217318 0.79 MAPT (0.49) MAPTPLECKDRMEN1KMT2A
SCHEMBL4215640 0.77 MEN1 (0.52) MEN1KMT2ATDP1RECQLBLM
SCHEMBL4221452 0.76 TDP1 (0.51) MAPTMEN1KMT2ASMN1; SMN2ALDH1A1
SCHEMBL4225414 0.76 KMT2A (0.51) MAPTMEN1KMT2APOLBALDH1A1
SCHEMBL4219603 0.76 MEN1 (0.51) MEN1KMT2ASMN1; SMN2TDP1RECQL
SCHEMBL4217206 0.76 MEN1 (0.61) MAPTMEN1KMT2ALMNATDP1
SCHEMBL4225455 0.76 MEN1 (0.66) MAPTMEN1KMT2ASMN1; SMN2POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8327467-B2 Anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO., LTD. (JP) 2012-12-11 — — US disclosed
EP-1860098-B1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO LTD (JP) 2012-11-14 — — EP disclosed
US-20090105474-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2009-04-23 — — US disclosed
EP-1860098-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2007-11-28 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090105474-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF MMP13, MMP11, MMP3 GLO1 2726/4885MAPT 4791/4885EGLN1 1156/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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