SCHEMBL4212902

SCHEMBL4212902

CS(=O)(=O)Nc1ccc(-c2ccc(C(=O)O)c(Nc3ccc4sccc4c3)c2)cc1

nearest known ligand 0.43

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
CA2 P00918 6/20 0.43
CA12 O43570 5/20 0.43
CSNK2A1 P68400 1/20 0.41
ACLY P53396 8/20 0.40
MCL1 Q07820 1/20 0.40
HDAC6 Q9UBN7 1/20 0.39
HSD17B1 P14061 1/20 0.39
HSD17B2 P37059 1/20 0.39
PIK3CD O00329 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4211168 0.87 MEN1 (0.46) CA2CA12CSNK2A1ACLY
SCHEMBL4215697 0.86 CA2 (0.41) CA2CA12CSNK2A1HDAC6HSD17B1
SCHEMBL14392064 0.84 CSNK2A1 (0.43) CA2CA12CSNK2A1ACLY
SCHEMBL4215632 0.81 CSNK2A1 (0.42) CSNK2A1ACLY
SCHEMBL4221471 0.81 ACLY (0.54) ACLYMCL1
SCHEMBL4217462 0.80 AKR1C3 (0.47) CSNK2A1ACLY
SCHEMBL4214892 0.79 CSNK2A1 (0.49) CA2CA12CSNK2A1PIK3CD
SCHEMBL4229254 0.78 ACLY (0.48) ACLYMCL1
SCHEMBL14392277 0.78 MEN1 (0.44) CA2CA12CSNK2A1ACLYPIK3CD
SCHEMBL9593575 0.76 CA2 (0.48) CA2CA12

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8327467-B2 Anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO., LTD. (JP) 2012-12-11 US disclosed
US-8327467-B2 Anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO., LTD. (JP) 2012-12-11 US disclosed
EP-1860098-B1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO LTD (JP) 2012-11-14 EP disclosed
US-20090105474-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2009-04-23 US disclosed
US-20090105474-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2009-04-23 US disclosed
EP-1860098-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2007-11-28 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090105474-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF MMP13, MMP11, MMP3 CA2 45/4885CA12 57/4885CSNK2A1 1640/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.