Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 1/20 | 0.58 |
| ▸ | CES2 | O00748 | 2/20 | 0.46 |
| ▸ | CES1 | P23141 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.43 |
| ▸ | LTA4H | P09960 | 1/20 | 0.43 |
| ▸ | LSS | P48449 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | FLT1 | P17948 | 1/20 | 0.41 |
| ▸ | FLT4 | P35916 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5307521 | 0.89 | CES2 (0.55) | DGAT1CES2CES1KMT2ANPC1 | |
| SCHEMBL3467995 | 0.88 | DGAT1 (0.56) | DGAT1KMT2ANPC1ALDH1A1LMNA | |
| SCHEMBL3025807 | 0.86 | KMT2A (0.61) | DGAT1KMT2ANPC1ALDH1A1LMNA | |
| SCHEMBL1128877 | 0.86 | MAPT (0.62) | DGAT1KMT2ANPC1ALDH1A1LMNA | |
| SCHEMBL8609990 | 0.85 | CES2 (0.63) | CES2CES1KMT2AALDH1A1LMNA | |
| SCHEMBL29880739 | 0.85 | CES2 (0.63) | CES2CES1KMT2AALDH1A1LMNA | |
| SCHEMBL4464312 | 0.85 | DGAT1 (0.70) | DGAT1CES2CES1KMT2ANPC1 | |
| SCHEMBL2989871 | 0.84 | HPGD (0.47) | DGAT1CES2CES1KMT2ANPC1 | |
| SCHEMBL5235450 | 0.83 | AKR1C3 (0.57) | DGAT1ALDH1A1MAPTPOLBAKR1C3 | |
| SCHEMBL5235158 | 0.83 | AKR1C3 (0.57) | DGAT1ALDH1A1MAPTPOLBAKR1C3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12540130-B2 | Substituted pyrrolidine amides IV | GRUENENTHAL GMBH (DE) | 2026-02-03 | — | — | US | disclosed |
| EP-3986885-B1 | SUBSTITUTED PYRROLIDINE AMIDES IV | GRUENENTHAL GMBH (DE) | 2023-05-03 | — | — | EP | disclosed |
| EP-3986885-B1 | SUBSTITUTED PYRROLIDINE AMIDES IV | GRUENENTHAL GMBH (DE) | 2023-05-03 | — | — | EP | disclosed |
| EP-3986885-A1 | SUBSTITUTED PYRROLIDINE AMIDES IV | Grünenthal GmbH (DE) | 2022-04-27 | — | — | EP | disclosed |
| US-20220106295-A1 | SUBSTITUTED PYRROLIDINE AMIDES IV | GRUENENTHAL GMBH (DE) | 2022-04-07 | — | — | US | disclosed |
| WO-2020254551-A1 | SUBSTITUTED PYRROLIDINE AMIDES IV | Grünenthal GmbH (DE) | 2020-12-24 | — | — | WO | disclosed |
| WO-2020254551-A1 | SUBSTITUTED PYRROLIDINE AMIDES IV | Grünenthal GmbH (DE) | 2020-12-24 | — | — | WO | disclosed |
| EP-3138842-B1 | POLYFLUORINATED COMPOUNDS ACTING AS BRUTON'S TYROSINE KINASE INHIBITORS | ZHEJIANG DTRM BIOPHARMA CO LTD (CN) | 2020-12-09 | — | — | EP | disclosed |
| EP-3138842-B1 | POLYFLUORINATED COMPOUNDS ACTING AS BRUTON'S TYROSINE KINASE INHIBITORS | ZHEJIANG DTRM BIOPHARMA CO LTD (CN) | 2020-12-09 | — | — | EP | disclosed |
| US-10300066-B2 | Polyfluorinated compounds acting as bruton tyrosine kinase inhibitors | Zhejiang DTRM Biopharma Co. Ltd. (CN) | 2019-05-28 | — | — | US | disclosed |
| US-20160200730-A1 | POLYFLUORINATED COMPOUNDS ACTING AS BRUTON TYROSINE KINASE INHIBITORS | Zhejiang DTRM Biopharma Co. Ltd. (CN) | 2016-07-14 | — | — | US | disclosed |
| US-20160200730-A1 | POLYFLUORINATED COMPOUNDS ACTING AS BRUTON TYROSINE KINASE INHIBITORS | Zhejiang DTRM Biopharma Co. Ltd. (CN) | 2016-07-14 | — | — | US | disclosed |
| US-20160200730-A1 | POLYFLUORINATED COMPOUNDS ACTING AS BRUTON TYROSINE KINASE INHIBITORS | Zhejiang DTRM Biopharma Co. Ltd. (CN) | 2016-07-14 | — | — | US | disclosed |
| WO-2015165279-A1 | POLYFLUORINATED COMPOUNDS ACTING AS BRUTON'S TYROSINE KINASE INHIBITORS | 浙江导明医药科技有限公司 | 2015-11-05 | — | — | WO | disclosed |
| US-20090023725-A1 | Fused Heteroaryl Derivatives for Use as P38 Kinase Inhibitors | SMITHKLINE BEECHAM CORPORATION | 2009-01-22 | — | — | US | disclosed |
| US-20090023725-A1 | Fused Heteroaryl Derivatives for Use as P38 Kinase Inhibitors | SMITHKLINE BEECHAM CORPORATION | 2009-01-22 | — | — | US | disclosed |
| US-20090023725-A1 | Fused Heteroaryl Derivatives for Use as P38 Kinase Inhibitors | SMITHKLINE BEECHAM CORPORATION | 2009-01-22 | — | — | US | disclosed |
| EP-1708996-B1 | FUSED HETEROYRAL DERIVATIVES FOR USE AS P38 KINASE INHIBITORS | SMITHKLINE BEECHAM CORP (US) | 2008-08-27 | — | — | EP | disclosed |
| EP-1708996-A1 | FUSED HETEROYRAL DERIVATIVES FOR USE AS P38 KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2006-10-11 | — | — | EP | disclosed |
| WO-2005073189-A1 | FUSED HETEROYRAL DERIVATIVES FOR USE AS P38 KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2005-08-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160200730-A1 | POLYFLUORINATED COMPOUNDS ACTING AS BRUTON TYROSINE KINASE INHIBITORS | BTK, LCK, LYN | DGAT1 3157/4885CES2 2531/4885CES1 2235/4885 |
| US-12540130-B2 | Substituted pyrrolidine amides IV | NR3C1, NR3C2, CRHR1 | DGAT1 1942/4885CES2 1134/4885CES1 330/4885 |
| US-20090023725-A1 | Fused Heteroaryl Derivatives for Use as P38 Kinase Inhibitors | MAPK1, MAPKAPK2, MAPK7 | DGAT1 3304/4885CES2 3964/4885CES1 2339/4885 |
| US-20220106295-A1 | SUBSTITUTED PYRROLIDINE AMIDES IV | NR3C1, NR3C2, MC2R | DGAT1 3638/4885CES2 2185/4885CES1 1207/4885 |
| US-10300066-B2 | Polyfluorinated compounds acting as bruton tyrosine kinase inhibitors | BTK, LCK, LYN | DGAT1 3157/4885CES2 2531/4885CES1 2235/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.