Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR3 | P49019 | 9/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.45 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.41 |
| ▸ | ACSS2 | Q9NR19 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3656285 | 0.87 | FGFR1 (0.39) | HCAR3TDP1FGFR1NPC1RAB9A | |
| SCHEMBL5982464 | 0.87 | HCAR3 (0.55) | HCAR3TDP1HPGDHCAR2HSD17B10 | |
| SCHEMBL3648771 | 0.83 | ACSS2 (0.49) | TDP1ESR2ACSS2 | |
| SCHEMBL7474034 | 0.83 | HTT (0.46) | TDP1FGFR1NPC1RAB9AMEN1 | |
| SCHEMBL3651101 | 0.83 | ACSS2 (0.42) | HPGDACSS2HSD17B10TSHRALDH1A1 | |
| SCHEMBL3649032 | 0.79 | CA12 (0.48) | NPC1RAB9AMEN1KMT2AHPGD | |
| SCHEMBL4223848 | 0.77 | ACSS2 (0.51) | TDP1MEN1KMT2AHPGDKDM4E | |
| SCHEMBL7815237 | 0.75 | ESR1 (0.37) | MEN1KMT2AHPGDKDM4EHSD17B10 | |
| SCHEMBL7487789 | 0.73 | GRN (0.40) | ACSS2 | |
| SCHEMBL5983851 | 0.73 | FGFR1 (0.46) | HCAR3FGFR1NPC1RAB9AHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101842365-A | The phenyl isoquinolin quinoline and the phenylquinazoline derivates that are used for the treatment of osteopathia | NOVARTIS AG | 2010-09-22 | — | — | CN | claimed |
| CN-101842365-A | The phenyl isoquinolin quinoline and the phenylquinazoline derivates that are used for the treatment of osteopathia | NOVARTIS AG | 2010-09-22 | — | — | CN | disclosed |
| US-20090074791-A1 | Phenylisoquinoline and Phenylquinazoline Derivatives | BEERLI RENE | 2009-03-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090074791-A1 | Phenylisoquinoline and Phenylquinazoline Derivatives | CAMK1D, CAMK1, PHPT1 | HCAR3 367/4885TDP1 3021/4885FGFR1 821/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.