Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 2/20 | 0.60 |
| ▸ | SERPINA6 | P08185 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | SHBG | P04278 | 2/20 | 0.57 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.57 |
| ▸ | THRB | P10828 | 1/20 | 0.57 |
| ▸ | PGR | P06401 | 5/20 | 0.52 |
| ▸ | ABCB11 | O95342 | 3/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.52 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.52 |
| ▸ | ESR1 | P03372 | 1/20 | 0.52 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.52 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.52 |
| ▸ | AR | P10275 | 4/20 | 0.51 |
| ▸ | NR3C2 | P08235 | 2/20 | 0.51 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4107834 | 0.83 | CYP19A1 (0.55) | CYP19A1SERPINA6ALDH1A1SHBGSLC22A1 | |
| SCHEMBL4225779 | 0.83 | AR (0.60) | CYP19A1SERPINA6ALDH1A1SHBGSLC22A1 | |
| SCHEMBL922877 | 0.80 | CYP19A1 (0.66) | CYP19A1SERPINA6ALDH1A1SHBGSLC22A1 | |
| SCHEMBL2830563 | 0.80 | CYP19A1 (0.78) | CYP19A1SERPINA6ALDH1A1SHBGSLC22A1 | |
| SCHEMBL11977689 | 0.80 | CYP19A1 (0.66) | CYP19A1SERPINA6ALDH1A1SHBGSLC22A1 | |
| SCHEMBL13216466 | 0.80 | CYP19A1 (0.66) | CYP19A1SERPINA6ALDH1A1SHBGSLC22A1 | |
| SCHEMBL19608861 | 0.80 | CYP19A1 (0.66) | CYP19A1SERPINA6ALDH1A1SHBGSLC22A1 | |
| SCHEMBL26425075 | 0.80 | CYP19A1 (0.66) | CYP19A1SERPINA6ALDH1A1SHBGSLC22A1 | |
| SCHEMBL6241693 | 0.78 | CYP19A1 (0.56) | CYP19A1SERPINA6ALDH1A1SHBGSLC22A1 | |
| SCHEMBL13372682 | 0.76 | ALDH1A1 (0.67) | CYP19A1SERPINA6ALDH1A1SHBGSLC22A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2170925-B1 | 17ß -CYANO-19-NOR-ANDROST-4-ENE DERIVATIVE, USE THEREOF AND MEDICAMENTS CONTAINING SAID DERIVATIVE | BAYER IP GMBH (DE) | 2012-10-24 | — | — | EP | disclosed |
| US-8207150-B2 | 17β-cyano-19-nor-androst-4-ene derivative, its use and medicaments comprising the derivative | Bayer Pharma AG (DE) | 2012-06-26 | — | — | US | disclosed |
| US-20090048217-A1 | 17Beta-CYANO-19-NOR-ANDROST-4-ENE DERIVATIVE, ITS USE AND MEDICAMENTS COMPRISING THE DERIVATIVE | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2009-02-19 | — | — | US | disclosed |
| EP-0137434-A2 | Estrane and androstane derivatives, process for their preparation and pharmaceutical preparations containing them | SCHERING AKTIENGESELLSCHAFT (DE) | 1985-04-17 | — | — | EP | disclosed |
| US-4036695-A | Process for the preparation of estrene-3,17-dione derivatives | SCHERING AKTIENGESELLSCHAFT (DT) | 1977-07-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090048217-A1 | 17Beta-CYANO-19-NOR-ANDROST-4-ENE DERIVATIVE, ITS USE AND MEDICAMENTS COMPRISING THE DERIVATIVE | HSD17B11, HSD17B7, NR5A1 | CYP19A1 14/4885SERPINA6 860/4885ALDH1A1 678/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.