Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPY1R | P25929 | 1/20 | 0.38 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.38 |
| ▸ | HRH4 | Q9H3N8 | 3/20 | 0.36 |
| ▸ | APP | P05067 | 2/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.33 |
| ▸ | PRKCH | P24723 | 1/20 | 0.33 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.33 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL602599 | 0.78 | HRH4 (0.47) | HRH4 | |
| SCHEMBL11219384 | 0.74 | HRH4 (0.41) | NPY1RNPY5RHRH4PRKCHPRKCE | |
| SCHEMBL3996679 | 0.67 | HRH4 (0.39) | HRH4 | |
| SCHEMBL8281898 | 0.62 | ALDH1A1 (0.47) | — | |
| SCHEMBL430482 | 0.62 | CXCR4 (0.40) | CXCR4 | |
| SCHEMBL7204411 | 0.61 | CXCR4 (0.55) | HRH4CXCR4 | |
| SCHEMBL2087271 | 0.61 | GRIN2D (0.46) | — | |
| SCHEMBL8264050 | 0.61 | XDH (0.51) | — | |
| SCHEMBL10485477 | 0.61 | NPY1R (0.36) | NPY1RNPY5RAPPCXCR4 | |
| SCHEMBL18263432 | 0.60 | GRIN2B (0.61) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2124560-A1 | 2-AMINOPYRIMIDINE MODULATORS OF THE HISTAMINE H4 RECEPTOR | Janssen Pharmaceutica, N.V. (BE) | 2009-12-02 | — | — | EP | disclosed |
| WO-2008100565-A1 | 2-AMINOPYRIMIDINE MODULATORS OF THE HISTAMINE H4 RECEPTOR | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-08-21 | — | — | WO | disclosed |