4-Amino-[1,2]Naphthoquinone

4-Amino-[1,2]Naphthoquinone

SCHEMBL422308

NC1=CC(=O)C(=O)c2ccccc21

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PTPN1 P18031 7/20 1.00
NSD2 O96028 2/20 1.00
HKDC1 Q2TB90 1/20 1.00
PTPRC P08575 4/20 0.56
KDM4E B2RXH2 3/20 0.56
MAPT P10636 3/20 0.56
ALDH1A1 P00352 2/20 0.56
MAPK1 P28482 2/20 0.56
CYP3A4 P08684 1/20 0.56
HPGD P15428 1/20 0.56
PTPN22 Q9Y2R2 1/20 0.56
TDP2 O95551 2/20 0.55
PAX8 Q06710 1/20 0.55
CDC25B P30305 2/20 0.52
PTPRF P10586 1/20 0.52
MEN1 O00255 3/20 0.50
KMT2A Q03164 3/20 0.50
POLB P06746 2/20 0.50
HTT P42858 2/20 0.50
MALT1 Q9UDY8 2/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
4-Amino-[1,2]Naphthoquinone SCHEMBL5051876 0.98 PTPN1 (0.95) PTPN1NSD2HKDC1PTPRCKDM4E
4-Amino-[1,2]Naphthoquinone SCHEMBL5161711 0.98 PTPN1 (0.95) PTPN1NSD2HKDC1PTPRCKDM4E
SCHEMBL29429719 0.81 PTPN1 (0.68) PTPN1NSD2HKDC1PTPRCKDM4E
SCHEMBL228360 0.81 PTPN1 (0.68) PTPN1NSD2HKDC1PTPRCKDM4E
SCHEMBL21048149 0.76 PTPN1 (0.63) PTPN1NSD2HKDC1PTPRCKDM4E
SCHEMBL8600693 0.75 PTPN1 (0.75) PTPN1NSD2HKDC1PTPRCKDM4E
Sulfuric Acid SCHEMBL10338517 0.74 HKDC1 (0.59) PTPN1NSD2HKDC1KDM4EMAPT
SCHEMBL6052798 0.73 PTPN1 (0.58) PTPN1NSD2HKDC1PTPRCKDM4E
SCHEMBL8994836 0.71 PTPN1 (0.56) PTPN1NSD2HKDC1PTPRCKDM4E
SCHEMBL4647848 0.71 CDC25B (0.68) PTPN1NSD2HKDC1PTPRCKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 63 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240141131-A1 ANTIPOLYMERANT COMPOSITIONS WITH NAPHTHOQUINONE AND HYDROXYLAMINE AND METHODS OF USING ECOLAB USA INC. 2024-05-02 US claimed
US-20200339880-A1 OXYGENATED AMINOPHENOL COMPOUNDS AND METHODS FOR PREVENTING MONOMER POLYMERIZATION ECOLAB USA INC. 2020-10-29 US claimed
US-20120205591-A1 SELF INDICATING RADIATION ALERT DOSIMETER PATEL GORDHABHAI N (US) 2012-08-16 US claimed
WO-2010042500-A2 HEAT SHOCK PROTEIN 90 INHIBITORS, METHODS OF PREPARING SAME, AND METHODS FOR THEIR USE EMORY UNIVERSITY (US) 2010-04-15 WO claimed
US-6540923-B2 For adding to boiler feed water; useful in inhibiting the corrosion in a boiler system by removing dissolved oxygen KURITA WATER INDUSTRIES LTD. (JP) 2003-04-01 US claimed
US-20020100896-A1 For adding to boiler feed water; useful in inhibiting the corrosion in a boiler system by removing dissolved oxygen KURITA WATER INDUSTRIES LTD. 2002-08-01 US claimed
EP-0515379-A4 ELECTRO-BLOTTING OF ELECTROPHORETICALLY RESOLVED FLUORESCENT-LABELED SACCHARIDES AND DETECTION OF ACTIVE STRUCTURES WITH PROTEIN PROBES GLYCOMED INC (US) 1994-09-14 EP claimed
EP-0515379-A1 ELECTRO-BLOTTING OF ELECTROPHORETICALLY RESOLVED FLUORESCENT-LABELED SACCHARIDES AND DETECTION OF ACTIVE STRUCTURES WITH PROTEIN PROBES GLYCOMED INCORPORATED (US) 1992-12-02 EP claimed
WO-1991012276-A1 ELECTRO-BLOTTING OF ELECTROPHORETICALLY RESOLVED FLUORESCENT-LABELED SACCHARIDES AND DETECTION OF ACTIVE STRUCTURES WITH PROTEIN PROBES GLYCOMED INCORPORATED (US) 1991-08-22 WO claimed
US-20240141131-A1 ANTIPOLYMERANT COMPOSITIONS WITH NAPHTHOQUINONE AND HYDROXYLAMINE AND METHODS OF USING ECOLAB USA INC. 2024-05-02 US disclosed
US-11312793-B2 Amino-quinone antipolymerants and methods of using ECOLAB USA INC. (US) 2022-04-26 US disclosed
US-20200102408-A1 AMINO-QUINONE ANTIPOLYMERANTS AND METHODS OF USING ECOLAB USA INC. 2020-04-02 US disclosed
CN-107875405-A Application of the labelled with radioisotope naphthoquinone compound in necrotic myocardium imaging 中国药科大学 2018-04-06 CN disclosed
US-20170023681-A1 PERSONAL AND SELF INDICATING RADIATION ALERT DOSIMETER NEW YORK UNIVERSITY 2017-01-26 US disclosed
US-5684035-A NAPHTHOQUINONES KAPADIA GOVIND J (US) 1997-11-04 US disclosed
WO-1997031936-A2 NOVEL ORTHO-NAPHTHOQUINONE DERIVATIVES, NOVEL SYNTHESIS THEREFOR, AND THEIR USE IN THE INHIBITION OF NEOPLASTIC CELL GROWTH WISCONSIN ALUMNI RESEARCH FOUNDATION (US) 1997-09-04 WO disclosed
EP-0713491-A1 SPIRO(INDOLINO) OXAZINE PHOTOCHROMIC COMPOUNDS PILKINGTON PLC (GB) 1996-05-29 EP disclosed
WO-1995005385-A1 SPIRO(INDOLINO) OXAZINE PHOTOCHROMIC COMPOUNDS PILKINGTON PLC (GB) 1995-02-23 WO disclosed
US-4801744-A SELENIUM CATALYST SOLVAY & CIE (SOCIETE ANONYME) (BE) 1989-01-31 US disclosed
EP-0193982-A1 Process for the catalytic preparation of nitrogen-containing organic compounds, especially ureas and their polymers SOLVAY & Cie (Société Anonyme) (BE) 1986-09-10 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200339880-A1 OXYGENATED AMINOPHENOL COMPOUNDS AND METHODS FOR PREVENTING MONOMER POLYMERIZATION HPD, DNPEP, PAH PTPN1 2874/4885NSD2 1237/4885HKDC1 4229/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.