SCHEMBL4225544

SCHEMBL4225544

CC(C)(C)[Si](C)(C)OCc1cc[c]cc1

nearest known ligand 0.32

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
BACE1 P56817 1/20 0.32
DUT P33316 2/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3403690 0.84 DUT (0.43) DUT
SCHEMBL8545478 0.81 DUT (0.36) DUT
SCHEMBL1315036 0.80 IDO1 (0.46) BACE1
SCHEMBL28326219 0.79
SCHEMBL5342752 0.79 BACE1 (0.32) BACE1
SCHEMBL1008605 0.79
SCHEMBL15489965 0.78 TDP1 (0.37) BACE1DUT
SCHEMBL906834 0.78 IDO1 (0.48) BACE1
SCHEMBL12855670 0.78 AGXT (0.52)
SCHEMBL581041 0.78 LOXL2 (0.37) BACE1DUT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 49 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3049386-B9 COMPOUNDS USEFUL IN THE TREATMENT OF NEOPLASTIC DISEASES UNIV KOELN (DE) 2020-11-18 EP claimed
EP-3049386-B1 COMPOUNDS USEFUL IN THE TREATMENT OF NEOPLASTIC DISEASES UNIV KOELN (DE) 2020-07-22 EP claimed
CN-118201644-A Ligand compounds comprising chelating groups as bridging groups 慕尼黑工业大学 2024-06-14 CN disclosed
CN-117320759-A Radiopharmaceutical somatostatin receptor ligands and precursors thereof 慕尼黑工业大学 2023-12-29 CN disclosed
CN-113677375-A Fluorinated silicon receptor substituted radiopharmaceuticals and precursors thereof 慕尼黑工业大学 2021-11-19 CN disclosed
US-20210085700-A1 TARGETED THERAPEUTICS MADRIGAL PHARMACEUTICALS, INC. 2021-03-25 US disclosed
EP-3049386-B9 COMPOUNDS USEFUL IN THE TREATMENT OF NEOPLASTIC DISEASES UNIV KOELN (DE) 2020-11-18 EP disclosed
EP-3738594-A1 TARGETED THERAPEUTICS HAVING AN HSP90 LIGAND AS BINDING MOIETY Madrigal Pharmaceuticals, Inc. (US) 2020-11-18 EP disclosed
US-10828315-B2 Targeted therapeutics MADRIGAL PHARMACEUTICALS, INC. (US) 2020-11-10 US disclosed
US-20200316090-A1 TARGETED THERAPEUTICS SYNTA PHARMACEUTICALS CORP. 2020-10-08 US disclosed
US-10793509-B2 Compounds useful in the treatment of neoplastic diseases UNIVERSITÄT ZU KOLN (DE) 2020-10-06 US disclosed
CN-1423645-A Vitamin D analogues GALDERMA RES & DEV (FR) 2003-06-11 CN disclosed
US-6197905-B1 VINYL ETHER CHAIN TRANSFER AGENT TERMINATES THE GROWTH OF THE POLYMER CHAIN BY ADDITION TO THE PROPAGATING POLYMER RADICAL FOLLOWED BY EXPULSION OF A RADICAL WHICH THEN INITIATES ANOTHER POLYMER CHAIN COMMONWEALTH SCIENTIFIC & INDUSTRIAL RESARCH ORGANIZATION (AU) 2001-03-06 US disclosed
US-5932675-A Free-radical chain transfer polymerization process COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION (AU) 1999-08-03 US disclosed
US-5874511-A CHAIN TRANSFER E. I. DU PONT DE NEMOURS AND COMPANY (US) 1999-02-23 US disclosed
EP-0333758-B1 CONTROL OF MOLECULAR WEIGHT AND END GROUP FUNCTIONALITY OF POLYMERS COMMW SCIENT IND RES ORG (AU) 1995-11-02 EP disclosed
US-5385996-A Control of molecular weight and end-group functionality of polymers COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION (AU) 1995-01-31 US disclosed
EP-0333758-A4 CONTROL OF MOLECULAR WEIGHT AND END GROUP FUNCTIONALITY OF POLYMERS. COMMW SCIENT IND RES ORG (AU) 1990-05-14 EP disclosed
EP-0333758-A1 CONTROL OF MOLECULAR WEIGHT AND END GROUP FUNCTIONALITY OF POLYMERS. COMMW SCIENT IND RES ORG (AU) 1989-09-27 EP disclosed
WO-1988004304-A1 CONTROL OF MOLECULAR WEIGHT AND END GROUP FUNCTIONALITY OF POLYMERS COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH OR (AU) 1988-06-16 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200316090-A1 TARGETED THERAPEUTICS CDC37, HSP90AB1, HSP90B1 BACE1 4399/4885DUT 278/4885
US-10793509-B2 Compounds useful in the treatment of neoplastic diseases APC, BRCA1, VHL BACE1 4120/4885DUT 932/4885
US-20210085700-A1 TARGETED THERAPEUTICS CDC37, HSP90AB1, HSP90B1 BACE1 4399/4885DUT 278/4885
US-10828315-B2 Targeted therapeutics CDC37, HSP90AB1, HSP90B1 BACE1 4399/4885DUT 278/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.