Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Terephthalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.80 |
| ▸ | TP53 | P04637 | 1/20 | 0.80 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.68 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.68 |
| ▸ | SRD5A2 | P31213 | 4/20 | 0.67 |
| ▸ | CA1 | P00915 | 4/20 | 0.63 |
| ▸ | CA2 | P00918 | 4/20 | 0.63 |
| ▸ | CA12 | O43570 | 2/20 | 0.63 |
| ▸ | CA3 | P07451 | 2/20 | 0.63 |
| ▸ | CA6 | P23280 | 2/20 | 0.63 |
| ▸ | CA5A | P35218 | 2/20 | 0.63 |
| ▸ | CA7 | P43166 | 2/20 | 0.63 |
| ▸ | CA9 | Q16790 | 2/20 | 0.63 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.63 |
| ▸ | CA5B | Q9Y2D0 | 2/20 | 0.63 |
| ▸ | TYR | P14679 | 1/20 | 0.63 |
| ▸ | DRD1 | P21728 | 1/20 | 0.63 |
| ▸ | CA4 | P22748 | 1/20 | 0.63 |
| ▸ | DAO | P14920 | 1/20 | 0.61 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Terephthalic Acid SCHEMBL19665047 | 1.00 | TSHR (0.80) | TSHRTP53ALDH1A1SMN1; SMN2SRD5A2 | |
| Terephthalic Acid SCHEMBL27400233 | 0.90 | TSHR (0.86) | TSHRTP53ALDH1A1SMN1; SMN2SRD5A2 | |
| Terephthalic Acid SCHEMBL11416580 | 0.90 | TSHR (0.86) | TSHRTP53ALDH1A1SMN1; SMN2SRD5A2 | |
| Terephthalic Acid SCHEMBL1403625 | 0.90 | TSHR (0.86) | TSHRTP53ALDH1A1SMN1; SMN2SRD5A2 | |
| Terephthalic Acid SCHEMBL1403607 | 0.90 | TSHR (0.86) | TSHRTP53ALDH1A1SMN1; SMN2SRD5A2 | |
| Terephthalic Acid SCHEMBL11858116 | 0.90 | TSHR (0.86) | TSHRTP53ALDH1A1SMN1; SMN2SRD5A2 | |
| Terephthalic Acid SCHEMBL175823 | 0.89 | TSHR (1.00) | TSHRTP53ALDH1A1SMN1; SMN2SRD5A2 | |
| Terephthalic Acid SCHEMBL1655 | 0.89 | TSHR (1.00) | TSHRTP53ALDH1A1SMN1; SMN2SRD5A2 | |
| Terephthalic Acid SCHEMBL5053781 | 0.89 | TSHR (1.00) | TSHRTP53ALDH1A1SMN1; SMN2SRD5A2 | |
| Terephthalic Acid SCHEMBL2511919 | 0.89 | TSHR (1.00) | TSHRTP53ALDH1A1SMN1; SMN2SRD5A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115260027-A | Stress sustained-release agent and preparation method and application thereof | 清华大学 | 2022-11-01 | — | — | CN | claimed |
| CN-115260027-B | Stress sustained release agent and preparation method and application thereof | 清华大学 | 2023-08-25 | — | — | CN | disclosed |
| CN-115260027-A | Stress sustained-release agent and preparation method and application thereof | 清华大学 | 2022-11-01 | — | — | CN | disclosed |
| CN-109181224-B | Composite shielding material containing MOF-derived porous gadolinium oxide and preparation method thereof | 中国科学院合肥物质科学研究院 | 2020-11-24 | — | — | CN | disclosed |
| US-20150306256-A1 | Lanthanide Nanoparticle Conjugates and Uses Thereof | COLORADO STATE UNIVERSITY RESEARCH FOUNDATION | 2015-10-29 | — | — | US | disclosed |
| US-8916135-B2 | Lanthanide nanoparticle conjugates and uses thereof | COLORADO SCHOOL OF MINES (US) | 2014-12-23 | — | — | US | disclosed |
| US-20090060840-A1 | Lanthanide Nanoparticle Conjugates and Uses Thereof | COLORADO STATE UNIVERSITY RESEARCH FOUNDATION | 2009-03-05 | — | — | US | disclosed |
| WO-2009026540-A1 | LANTHANIDE NANOPARTICLE CONJUGATES AND USES THEREOF | COLORADO SCHOOL OF MINES (US) | 2009-02-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150306256-A1 | Lanthanide Nanoparticle Conjugates and Uses Thereof | SSB, CD47, SLC6A13 | TSHR 406/4885TP53 950/4885ALDH1A1 3785/4885 |
| US-20090060840-A1 | Lanthanide Nanoparticle Conjugates and Uses Thereof | SSB, CD47, SLC6A13 | TSHR 406/4885TP53 950/4885ALDH1A1 3785/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.