Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Terephthalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.86 |
| ▸ | TP53 | P04637 | 1/20 | 0.86 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.72 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.72 |
| ▸ | SRD5A2 | P31213 | 4/20 | 0.71 |
| ▸ | CA1 | P00915 | 3/20 | 0.67 |
| ▸ | CA2 | P00918 | 3/20 | 0.67 |
| ▸ | CA12 | O43570 | 1/20 | 0.67 |
| ▸ | CA3 | P07451 | 1/20 | 0.67 |
| ▸ | TYR | P14679 | 1/20 | 0.67 |
| ▸ | DRD1 | P21728 | 1/20 | 0.67 |
| ▸ | CA4 | P22748 | 1/20 | 0.67 |
| ▸ | CA6 | P23280 | 1/20 | 0.67 |
| ▸ | CA5A | P35218 | 1/20 | 0.67 |
| ▸ | CA7 | P43166 | 1/20 | 0.67 |
| ▸ | CA9 | Q16790 | 1/20 | 0.67 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.67 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.67 |
| ▸ | DAO | P14920 | 1/20 | 0.65 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Terephthalic Acid SCHEMBL1403607 | 1.00 | TSHR (0.86) | TSHRTP53ALDH1A1SMN1; SMN2SRD5A2 | |
| Terephthalic Acid SCHEMBL16290828 | 0.96 | TSHR (0.92) | TSHRTP53ALDH1A1SMN1; SMN2SRD5A2 | |
| Terephthalic Acid SCHEMBL11416580 | 0.93 | TSHR (0.86) | TSHRTP53ALDH1A1SMN1; SMN2SRD5A2 | |
| Terephthalic Acid SCHEMBL175823 | 0.93 | TSHR (1.00) | TSHRTP53ALDH1A1SMN1; SMN2SRD5A2 | |
| Terephthalic Acid SCHEMBL1655 | 0.93 | TSHR (1.00) | TSHRTP53ALDH1A1SMN1; SMN2SRD5A2 | |
| Terephthalic Acid SCHEMBL2511919 | 0.93 | TSHR (1.00) | TSHRTP53ALDH1A1SMN1; SMN2SRD5A2 | |
| Terephthalic Acid SCHEMBL5053781 | 0.93 | TSHR (1.00) | TSHRTP53ALDH1A1SMN1; SMN2SRD5A2 | |
| Terephthalic Acid SCHEMBL29170961 | 0.91 | TSHR (0.71) | TSHRTP53ALDH1A1SMN1; SMN2SRD5A2 | |
| Terephthalic Acid SCHEMBL246842 | 0.91 | TSHR (0.71) | TSHRTP53ALDH1A1SMN1; SMN2SRD5A2 | |
| Terephthalic Acid SCHEMBL8209798 | 0.90 | TSHR (0.80) | TSHRTP53ALDH1A1SMN1; SMN2SRD5A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3898801-B1 | METHOD FOR RECYCLING PET PLASTIC WASTE | RECYCELIT (FR) | 2025-02-26 | — | — | EP | claimed |
| EP-2291433-A1 | MODIFIED POLYESTER RESIN | DSM IP Assets B.V. (NL) | 2011-03-09 | — | — | EP | claimed |
| WO-2009156457-A1 | MODIFIED POLYESTER RESIN | DSM IP ASSETS BV (NL) | 2009-12-30 | — | — | WO | claimed |
| US-12509585-B2 | Thermal conductive silicone composition | DUPONT TORAY SPECIALTY MATERIALS KABUSHIKI KAISHA (JP) | 2025-12-30 | — | — | US | disclosed |
| CN-118695935-A | Method for producing polymer molded parts | 图茨技术股份有限公司 | 2024-09-24 | — | — | CN | disclosed |
| CN-114650915-B | Layer structure with modified structure and production thereof | 科思创德国股份有限公司 | 2024-05-31 | — | — | CN | disclosed |
| CN-111542565-B | Plastic film with reduced UV activity | 科思创德国股份有限公司 | 2023-08-22 | — | — | CN | disclosed |
| US-20230159755-A1 | THERMAL CONDUCTIVE SILICONE COMPOSITION | DUROPTIX MATERIALS KABUSHIKI KAISHA (JP) | 2023-05-25 | — | — | US | disclosed |
| US-20230132793-A1 | Use of polyamide 6 | LANXESS Performance Materials GmbH (DE) | 2023-05-04 | — | — | US | disclosed |
| CN-116056595-A | Cartridge for vapor-generating system | 日本烟草国际股份有限公司 | 2023-05-02 | — | — | CN | disclosed |
| CN-116004014-A | Thermally conductive silicone composition | 杜邦东丽特殊材料株式会社 | 2023-04-25 | — | — | CN | disclosed |
| EP-2291433-B1 | MODIFIED POLYESTER RESIN | DSM IP ASSETS BV (NL) | 2016-02-24 | — | — | EP | disclosed |
| EP-2291433-A1 | MODIFIED POLYESTER RESIN | DSM IP Assets B.V. (NL) | 2011-03-09 | — | — | EP | disclosed |
| WO-2009156457-A1 | MODIFIED POLYESTER RESIN | DSM IP ASSETS BV (NL) | 2009-12-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12509585-B2 | Thermal conductive silicone composition | ILK, COL2A1, COL1A1 | TSHR 2222/4885TP53 3541/4885ALDH1A1 3417/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.