Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A known ✓ | Q03164 | 4/20 | 0.49 |
| ▸ | MEN1 known ✓ | O00255 | 2/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.58 |
| ▸ | CASR | P41180 | 1/20 | 0.49 |
| ▸ | KLK7 | P49862 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL4226822 | 1.00 | TDP1 (0.58) | TDP1KMT2AMEN1CASRKLK7 | |
| Fumaric Acid SCHEMBL4220532 | 0.93 | KMT2A (0.53) | TDP1KMT2AMEN1CASRALDH1A1 | |
| Fumaric Acid SCHEMBL4220524 | 0.93 | KMT2A (0.53) | TDP1KMT2AMEN1CASRALDH1A1 | |
| Fumaric Acid SCHEMBL4233829 | 0.90 | ALDH1A1 (0.50) | ALDH1A1SMN1; SMN2LMNA | |
| Fumaric Acid SCHEMBL4233827 | 0.90 | ALDH1A1 (0.50) | ALDH1A1SMN1; SMN2LMNA | |
| Fumaric Acid SCHEMBL5108111 | 0.85 | HRH1 (0.47) | KMT2AMEN1POLBLMNA | |
| Fumaric Acid SCHEMBL5108102 | 0.85 | HRH1 (0.47) | KMT2AMEN1POLBLMNA | |
| SCHEMBL4237244 | 0.84 | CYP1A2 (0.51) | KMT2AMEN1ALDH1A1SMN1; SMN2LMNA | |
| Fumaric Acid SCHEMBL4232774 | 0.83 | SMN1; SMN2 (0.56) | SMN1; SMN2 | |
| Fumaric Acid SCHEMBL4232765 | 0.83 | SMN1; SMN2 (0.56) | SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2096104-A1 | Organic diamines as mGluR7 modulators | Novartis AG (CH) | 2009-09-02 | — | — | EP | disclosed |