Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A known ✓ | Q03164 | 3/20 | 0.53 |
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 3/20 | 0.53 |
| ▸ | CASR | P41180 | 1/20 | 0.53 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.49 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.49 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL4220524 | 1.00 | KMT2A (0.53) | KMT2ANPC1CASRADRB3ALDH1A1 | |
| Fumaric Acid SCHEMBL4226822 | 0.93 | TDP1 (0.58) | KMT2ANPC1CASRADRB3ALDH1A1 | |
| Fumaric Acid SCHEMBL4226828 | 0.93 | TDP1 (0.58) | KMT2ANPC1CASRADRB3ALDH1A1 | |
| Fumaric Acid SCHEMBL4231652 | 0.89 | ALDH1A1 (0.58) | KMT2AALDH1A1MEN1 | |
| Fumaric Acid SCHEMBL4231644 | 0.89 | ALDH1A1 (0.58) | KMT2AALDH1A1MEN1 | |
| Fumaric Acid SCHEMBL4233829 | 0.84 | ALDH1A1 (0.50) | ALDH1A1TAAR1 | |
| Fumaric Acid SCHEMBL4233827 | 0.84 | ALDH1A1 (0.50) | ALDH1A1TAAR1 | |
| SCHEMBL4221974 | 0.84 | TACR1 (0.62) | KMT2ANPC1CASRADRB3MEN1 | |
| Fumaric Acid SCHEMBL4227185 | 0.84 | ALDH1A1 (0.47) | KMT2AALDH1A1MEN1 | |
| Fumaric Acid SCHEMBL4227194 | 0.84 | ALDH1A1 (0.47) | KMT2AALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2096104-A1 | Organic diamines as mGluR7 modulators | Novartis AG (CH) | 2009-09-02 | — | — | EP | disclosed |
| US-20080242698-A1 | Organic Compounds | NOVARTIS AG (CH) | 2008-10-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080242698-A1 | Organic Compounds | AOC1, OTC, ODC1 | KMT2A 1438/4885MEN1 464/4885NPC1 1929/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.