Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 known ✓ | P14416 | 8/20 | 0.66 |
| ▸ | HTR2B known ✓ | P41595 | 7/20 | 0.66 |
| ▸ | HTR2A known ✓ | P28223 | 6/20 | 0.66 |
| ▸ | HRH1 known ✓ | P35367 | 6/20 | 0.66 |
| ▸ | SLC6A4 known ✓ | P31645 | 3/20 | 0.66 |
| ▸ | HTR7 | P34969 | 9/20 | 0.66 |
| ▸ | DRD3 | P35462 | 8/20 | 0.66 |
| ▸ | HTR1A | P08908 | 7/20 | 0.66 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.56 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.56 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.56 |
| ▸ | NCOR2 | Q9Y618 | 2/20 | 0.56 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.54 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.51 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.51 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4229925 | 0.92 | HTR7 (0.73) | HTR7DRD2DRD3HTR1AHTR2B | |
| Hydrochloric Acid SCHEMBL4222979 | 0.90 | HTR7 (0.71) | HTR7DRD2DRD3HTR1AHTR2B | |
| SCHEMBL4225894 | 0.88 | HDAC3 (0.71) | HTR7DRD2DRD3HTR1AHTR2B | |
| Fumaric Acid SCHEMBL4232356 | 0.87 | HTR7 (0.62) | HTR7DRD2DRD3HTR1AHTR2B | |
| Hydrochloric Acid SCHEMBL4224096 | 0.86 | HDAC3 (0.69) | HTR7DRD2DRD3HTR1AHTR2B | |
| Oxalic Acid SCHEMBL4228870 | 0.85 | HDAC3 (0.68) | HTR7DRD2DRD3HTR1AHTR2B | |
| Hydrochloric Acid SCHEMBL4231320 | 0.85 | HDAC3 (0.71) | HTR7DRD2DRD3HTR1AHTR2B | |
| SCHEMBL3891857 | 0.84 | HDAC3 (0.68) | HTR7DRD2DRD3HTR1AHTR2B | |
| Hydrochloric Acid SCHEMBL4251907 | 0.83 | HDAC3 (0.67) | HTR7DRD2DRD3HTR1AHTR2B | |
| SCHEMBL8687907 | 0.83 | HTR7 (0.76) | HTR7DRD2DRD3HTR1AHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8188115-B2 | 5-HT7 receptor antagonists | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2012-05-29 | — | — | US | disclosed |
| US-20090163542-A1 | 5-ht7 receptor antagonists | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2009-06-25 | — | — | US | disclosed |
| US-7211585-B2 | 5-HT7 receptor antagonists | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2007-05-01 | — | — | US | disclosed |
| US-20060040978-A1 | 5-HT7 receptor antagonists | LABORATORIES DEL DR. ESTEVE, S.A. (ES) | 2006-02-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090163542-A1 | 5-ht7 receptor antagonists | HTR7, HTR1A, HTR5A | DRD2 39/4885HTR2B 4/4885HTR2A 6/4885 |
| US-20060040978-A1 | 5-HT7 receptor antagonists | HTR7, HTR1A, HTR5A | DRD2 39/4885HTR2B 4/4885HTR2A 6/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.