Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 4/20 | 0.50 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.50 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.50 |
| ▸ | AGTR2 | P50052 | 3/20 | 0.46 |
| ▸ | GBA1 | P04062 | 2/20 | 0.45 |
| ▸ | CHI3L1 | P36222 | 1/20 | 0.44 |
| ▸ | MC4R | P32245 | 2/20 | 0.41 |
| ▸ | MC3R | P41968 | 2/20 | 0.41 |
| ▸ | MC1R | Q01726 | 2/20 | 0.41 |
| ▸ | MITF | O75030 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3724429 | 1.00 | SLC6A2 (0.50) | SLC6A2SLC6A4SLC6A3AGTR2GBA1 | |
| SCHEMBL8188286 | 0.90 | AGTR2 (0.48) | SLC6A2SLC6A4SLC6A3AGTR2GBA1 | |
| SCHEMBL29729985 | 0.87 | GBA1 (0.50) | SLC6A2SLC6A4SLC6A3AGTR2GBA1 | |
| SCHEMBL8177314 | 0.85 | AGTR2 (0.49) | SLC6A2SLC6A4SLC6A3AGTR2GBA1 | |
| SCHEMBL5193918 | 0.84 | HTR3A (0.40) | SLC6A2SLC6A4SLC6A3CHI3L1 | |
| SCHEMBL18258630 | 0.82 | CHI3L1 (0.52) | AGTR2CHI3L1MC4RMC3RMC1R | |
| SCHEMBL4166236 | 0.77 | MAPK1 (0.43) | — | |
| SCHEMBL18608060 | 0.77 | CHI3L1 (0.58) | SLC6A3CHI3L1 | |
| SCHEMBL18589457 | 0.77 | CHI3L1 (0.58) | SLC6A3CHI3L1 | |
| Hydrochloric Acid SCHEMBL18577245 | 0.76 | CHI3L1 (0.57) | SLC6A3CHI3L1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2012759-A1 | PURINE DERIVATIVES AS A2A RECEPTOR AGONISTS | Novartis AG (CH) | 2009-01-14 | — | — | EP | disclosed |
| WO-2007121923-A1 | PURINE DERIVATIVES AS A2A RECEPTOR AGONISTS | NOVARTIS AG (CH) | 2007-11-01 | — | — | WO | disclosed |