Sugi Predict

Sugi Predict / Compounds / SCHEMBL4237998

SCHEMBL4237998

SCHEMBL4237998

Cc1ccc(NC(=O)Nc2cccc(CN3CCN(C(=O)OC(C)(C)C)CC3C)c2F)cn1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ GPR119 Q8TDV5 8/20 0.39
▸ MEN1 O00255 1/20 0.39
▸ MAPT P10636 1/20 0.39
▸ TSHR P16473 1/20 0.39
▸ KMT2A Q03164 1/20 0.39
▸ SMN1; SMN2 Q16637 1/20 0.39
▸ MAPK8 P45983 2/20 0.37
▸ MAPK10 P53779 2/20 0.37
▸ PARP1 P09874 1/20 0.37
▸ PARP2 Q9UGN5 1/20 0.37
▸ WNT3A P56704 1/20 0.36
▸ NPSR1 Q6W5P4 1/20 0.36
▸ TBK1 Q9UHD2 1/20 0.36
▸ RORC P51449 1/20 0.36
▸ DHODH Q02127 1/20 0.36
▸ USP30 Q70CQ3 1/20 0.36
▸ FPR1 P21462 1/20 0.36
▸ FPR2 P25090 1/20 0.36
▸ KEAP1 Q14145 1/20 0.36
▸ NFE2L2 Q16236 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4238002 1.00 GPR119 (0.39) GPR119MEN1MAPTTSHRKMT2A
SCHEMBL4239756 0.93 FPR1 (0.40) MEN1KMT2ASMN1; SMN2MAPK8MAPK10
SCHEMBL4239754 0.93 FPR1 (0.40) MEN1KMT2ASMN1; SMN2MAPK8MAPK10
SCHEMBL4241922 0.90 MAPK10 (0.38) GPR119MEN1MAPTTSHRKMT2A
SCHEMBL29714034 0.90 MAPK10 (0.38) GPR119MEN1MAPTTSHRKMT2A
SCHEMBL4241919 0.90 MAPK10 (0.38) GPR119MEN1MAPTTSHRKMT2A
SCHEMBL4246655 0.89 FPR1 (0.42) SMN1; SMN2MAPK8MAPK10NPSR1RORC
SCHEMBL4246650 0.89 FPR1 (0.42) SMN1; SMN2MAPK8MAPK10NPSR1RORC
SCHEMBL4246553 0.89 RORC (0.40) MEN1KMT2ASMN1; SMN2MAPK8MAPK10
SCHEMBL5014984 0.89 RORC (0.40) MEN1KMT2ASMN1; SMN2MAPK8MAPK10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1959947-A2 CERTAIN CHEMICAL ENTITIES, COMPOSITIONS AND METHODS Cytokinetics, Inc. (US) 2008-08-27 — — EP claimed
US-20070197505-A1 Certain chemical entities, compositions and methods CYTOKINETICS, INC. 2007-08-23 — — US claimed
WO-2007075377-A2 CERTAIN CHEMICAL ENTITIES, COMPOSITIONS AND METHODS CYTOKINETICS, INC. (US) 2007-07-05 — — WO claimed
US-20090247544-A1 Certain Chemical Entities, Compositions and Methods CYTOKINETICS, INC. 2009-10-01 — — US disclosed
EP-1959947-A2 CERTAIN CHEMICAL ENTITIES, COMPOSITIONS AND METHODS Cytokinetics, Inc. (US) 2008-08-27 — — EP disclosed
US-20070197505-A1 Certain chemical entities, compositions and methods CYTOKINETICS, INC. 2007-08-23 — — US disclosed
WO-2007075377-A2 CERTAIN CHEMICAL ENTITIES, COMPOSITIONS AND METHODS CYTOKINETICS, INC. (US) 2007-07-05 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070197505-A1 Certain chemical entities, compositions and methods TNNC1, TNNI3, TNNT2 GPR119 1088/4885MEN1 4493/4885MAPT 49/4885
US-20090247544-A1 Certain Chemical Entities, Compositions and Methods TNNC1, TNNI3, TNNT2 GPR119 1088/4885MEN1 4493/4885MAPT 49/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.