Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 2/20 | 0.67 |
| ▸ | CES2 | O00748 | 1/20 | 0.67 |
| ▸ | CYP2E1 | P05181 | 2/20 | 0.47 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.47 |
| ▸ | CYP2B6 | P20813 | 2/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.45 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.43 |
| ▸ | USP19 | O94966 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.41 |
| ▸ | MGLL | Q99685 | 1/20 | 0.41 |
| ▸ | GBA1 | P04062 | 3/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL426094 | 0.99 | FAAH (0.66) | FAAHCES2CYP2E1CYP2A6CYP2C9 | |
| SCHEMBL427890 | 0.90 | FAAH (0.55) | FAAHCES2CYP2E1CYP2A6CYP2C9 | |
| SCHEMBL424383 | 0.89 | FAAH (0.74) | FAAHCES2TRPV1USP19ALDH1A1 | |
| SCHEMBL427343 | 0.89 | FAAH (0.54) | FAAHCES2CYP2E1CYP2A6CYP2C9 | |
| SCHEMBL424221 | 0.89 | FAAH (0.54) | FAAHCES2CYP2E1CYP2A6CYP2C9 | |
| SCHEMBL426128 | 0.88 | FAAH (0.66) | FAAHCES2TRPV1HSP90AA1USP19 | |
| SCHEMBL427505 | 0.87 | FAAH (0.52) | FAAHCES2CYP2E1CYP2A6CYP2C9 | |
| SCHEMBL428153 | 0.87 | FAAH (0.52) | FAAHCES2CYP2E1CYP2A6CYP2C9 | |
| SCHEMBL424938 | 0.86 | FAAH (0.52) | FAAHCES2CYP2E1CYP2A6CYP2C9 | |
| SCHEMBL425456 | 0.85 | FAAH (0.53) | FAAHCES2CYP2E1CYP2A6CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11078163-B2 | Processes for the synthesis of substituted urea compounds | Bial-Portela & Cª, S.A. (PT) | 2021-08-03 | — | — | US | disclosed |
| US-20200140391-A1 | Processes for the Synthesis of Substituted Urea Compounds | BIAL-PORTELA & CA, S.A. (PT) | 2020-05-07 | — | — | US | disclosed |
| EP-3097082-B1 | PROCESSES FOR THE SYNTHESIS OF SUBSTITUTED UREA COMPOUNDS | BIAL PORTELA & CA SA (PT) | 2019-10-02 | — | — | EP | disclosed |
| EP-2606035-B1 | PROCES FOR THE SYNTHESIS OF SUBSTITUTED UREA COMPOUNDS | BIAL - PORTELA & CA S A (PT) | 2017-09-06 | — | — | EP | disclosed |
| EP-2606035-B1 | PROCES FOR THE SYNTHESIS OF SUBSTITUTED UREA COMPOUNDS | BIAL - PORTELA & CA S A (PT) | 2017-09-06 | — | — | EP | disclosed |
| US-20170001962-A1 | Processes for the Synthesis of Substituted Urea Compounds | Bial-Portela & Cª, S.A. (PT) | 2017-01-05 | — | — | US | disclosed |
| US-20170001962-A1 | Processes for the Synthesis of Substituted Urea Compounds | Bial-Portela & Cª, S.A. (PT) | 2017-01-05 | — | — | US | disclosed |
| US-9458111-B2 | Process for the synthesis of substituted urea compounds | BIAL—PORTELA & CA, S.A. (PT) | 2016-10-04 | — | — | US | disclosed |
| US-9458111-B2 | Process for the synthesis of substituted urea compounds | BIAL—PORTELA & CA, S.A. (PT) | 2016-10-04 | — | — | US | disclosed |
| US-9458111-B2 | Process for the synthesis of substituted urea compounds | BIAL—PORTELA & CA, S.A. (PT) | 2016-10-04 | — | — | US | disclosed |
| US-20130123493-A1 | PROCESS FOR THE SYNTHESIS OF SUBSTITUTED UREA COMPOUNDS | BIAL - PORTELA & CA, S.A. (PT) | 2013-05-16 | — | — | US | disclosed |
| US-20130123493-A1 | PROCESS FOR THE SYNTHESIS OF SUBSTITUTED UREA COMPOUNDS | BIAL - PORTELA & CA, S.A. (PT) | 2013-05-16 | — | — | US | disclosed |
| US-20120065191-A1 | PHARMACEUTICAL COMPOUNDS | BIAL - PORTELA & Cª, S.A. (PT) | 2012-03-15 | — | — | US | disclosed |
| US-20120065191-A1 | PHARMACEUTICAL COMPOUNDS | BIAL - PORTELA & Cª, S.A. (PT) | 2012-03-15 | — | — | US | disclosed |
| US-20120065191-A1 | PHARMACEUTICAL COMPOUNDS | BIAL - PORTELA & Cª, S.A. (PT) | 2012-03-15 | — | — | US | disclosed |
| WO-2012015324-A1 | PROCESS FOR THE SYNTHESIS OF SUBSTITUTED UREA COMPOUNDS | BIAL - PORTELA & CA, S.A. (PT) | 2012-02-02 | — | — | WO | disclosed |
| CN-102333568-A | Pharmaceutical compounds | BIAL PORTELA & CA SA | 2012-01-25 | — | — | CN | disclosed |
| EP-2382012-A2 | PHARMACEUTICAL COMPOUNDS | Bial-Portela & CA, S.A. (PT) | 2011-11-02 | — | — | EP | disclosed |
| WO-2010074588-A2 | PHARMACEUTICAL COMPOUNDS | BIAL - PORTELA & Cª, S.A. (PT) | 2010-07-01 | — | — | WO | disclosed |
| WO-2010074588-A2 | PHARMACEUTICAL COMPOUNDS | BIAL - PORTELA & Cª, S.A. (PT) | 2010-07-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130123493-A1 | PROCESS FOR THE SYNTHESIS OF SUBSTITUTED UREA COMPOUNDS | UTS2R, ARG1, PRMT1 | FAAH 2166/4885CES2 463/4885CYP2E1 411/4885 |
| US-20170001962-A1 | Processes for the Synthesis of Substituted Urea Compounds | H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, ODC1, REN | FAAH 2900/4885CES2 698/4885CYP2E1 293/4885 |
| US-20200140391-A1 | Processes for the Synthesis of Substituted Urea Compounds | GRHPR, REN, ODC1 | FAAH 3163/4885CES2 633/4885CYP2E1 216/4885 |
| US-20120065191-A1 | PHARMACEUTICAL COMPOUNDS | FAAH, FAAH2, ASAH1 | FAAH 1/4885CES2 62/4885CYP2E1 222/4885 |
| US-11078163-B2 | Processes for the synthesis of substituted urea compounds | GRHPR, REN, ODC1 | FAAH 3163/4885CES2 633/4885CYP2E1 216/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.