Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | PKM | P14618 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | RHEB | Q15382 | 1/20 | 0.43 |
| ▸ | XDH | P47989 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5029722 | 0.90 | KDM4E (0.57) | MAPTSMN1; SMN2MAPK1KDM4EALDH1A1 | |
| SCHEMBL22533987 | 0.85 | SMN1; SMN2 (0.55) | MAPTSMN1; SMN2MAPK1KDM4EALDH1A1 | |
| SCHEMBL6093891 | 0.84 | SMN1; SMN2 (0.57) | MAPTSMN1; SMN2MAPK1KDM4EALDH1A1 | |
| SCHEMBL4246402 | 0.84 | SMN1; SMN2 (0.54) | MAPTSMN1; SMN2MAPK1KDM4EALDH1A1 | |
| SCHEMBL2039522 | 0.84 | KDM4E (0.60) | MAPTSMN1; SMN2KDM4EALDH1A1MEN1 | |
| SCHEMBL15294555 | 0.83 | SMN1; SMN2 (0.53) | MAPTSMN1; SMN2MAPK1KDM4EALDH1A1 | |
| SCHEMBL8906504 | 0.83 | L3MBTL1 (0.54) | MAPTSMN1; SMN2MAPK1KDM4EALDH1A1 | |
| SCHEMBL3737238 | 0.83 | SMN1; SMN2 (0.53) | MAPTSMN1; SMN2MAPK1KDM4EALDH1A1 | |
| SCHEMBL23280119 | 0.81 | ALDH1A1 (0.47) | MAPTSMN1; SMN2MAPK1KDM4EALDH1A1 | |
| SCHEMBL8632161 | 0.81 | MAPT (0.55) | MAPTSMN1; SMN2MAPK1ALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090048252-A1 | THIAZOLONES FOR USE AS PI3 KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION | 2009-02-19 | — | — | US | disclosed |
| US-20070249599-A1 | Novel Chemical Compounds | DUFFY KEVIN J | 2007-10-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070249599-A1 | Novel Chemical Compounds | HIPK3, HIPK1, HIPK4 | MAPT 1769/4885SMN1; SMN2 2249/4885MAPK1 1623/4885 |
| US-20090048252-A1 | THIAZOLONES FOR USE AS PI3 KINASE INHIBITORS | PIK3CA, BTK, PI4KA | MAPT 2228/4885SMN1; SMN2 2523/4885MAPK1 1490/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.