Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.38 |
| ▸ | DPP4 | P27487 | 2/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.33 |
| ▸ | MYC | P01106 | 1/20 | 0.33 |
| ▸ | EED | O75530 | 7/20 | 0.33 |
| ▸ | SUZ12 | Q15022 | 7/20 | 0.33 |
| ▸ | EZH2 | Q15910 | 7/20 | 0.33 |
| ▸ | RBBP4 | Q09028 | 6/20 | 0.33 |
| ▸ | AEBP2 | Q6ZN18 | 6/20 | 0.33 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.33 |
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.32 |
| ▸ | RAF1 | P04049 | 1/20 | 0.32 |
| ▸ | EGFR | P00533 | 3/20 | 0.32 |
| ▸ | ABL1 | P00519 | 1/20 | 0.32 |
| ▸ | SRC | P12931 | 1/20 | 0.32 |
| ▸ | FLT1 | P17948 | 1/20 | 0.32 |
| ▸ | KDR | P35968 | 1/20 | 0.32 |
| ▸ | SYK | P43405 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4063577 | 0.83 | LRRK2 (0.48) | LRRK2MYCMAP2K1RAF1EGFR | |
| SCHEMBL4072632 | 0.78 | ALDH1A1 (0.42) | LRRK2ALDH1A1CYP1A2 | |
| SCHEMBL4072555 | 0.78 | LRRK2 (0.43) | LRRK2MYCMAP2K1RAF1EGFR | |
| SCHEMBL4572184 | 0.67 | LRRK2 (0.54) | LRRK2DPP4KCNH2MAP2K1RAF1 | |
| SCHEMBL27668508 | 0.65 | TLR7 (0.47) | LRRK2MAP2K1RAF1ALDH1A1CYP1A2 | |
| SCHEMBL7412699 | 0.65 | ALOX5 (0.42) | — | |
| SCHEMBL4231806 | 0.64 | LRRK2 (0.50) | LRRK2MAP2K1RAF1SRCPOLB | |
| SCHEMBL3156282 | 0.64 | LRRK2 (0.50) | LRRK2DPP4KCNH2MAP2K1RAF1 | |
| SCHEMBL27668262 | 0.63 | LRRK2 (0.57) | LRRK2DPP4KCNH2MAP2K1RAF1 | |
| SCHEMBL20494995 | 0.63 | ALDH1A1 (0.43) | MYCALDH1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1706412-A4 | NOVEL PYRIDINE DERIVATIVES, A PROCESS FOR THEIR PREPARATION AND A PHARMACEUTICAL COMPOSITION CONTAINING THE SAME | SK CHEMICALS CO LTD (KR) | 2009-03-18 | — | — | EP | disclosed |
| EP-1706412-A1 | NOVEL PYRIDINE DERIVATIVES, A PROCESS FOR THEIR PREPARATION AND A PHARMACEUTICAL COMPOSITION CONTAINING THE SAME | SK Chemicals, Co., Ltd. (KR) | 2006-10-04 | — | — | EP | disclosed |
| WO-2005063768-A1 | NOVEL PYRIDINE DERIVATIVES, A PROCESS FOR THEIR PREPARATION AND A PHARMACEUTICAL COMPOSITION CONTAINING THE SAME | SK CHEMICALS, CO., LTD. (KR) | 2005-07-14 | — | — | WO | disclosed |