Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Nitric Oxide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Nitric Oxide SCHEMBL7560 | 0.87 | — | — | |
| Nitric Oxide SCHEMBL3993955 | 0.87 | — | — | |
| Nitric Oxide SCHEMBL7184108 | 0.75 | — | — | |
| Nitric Oxide SCHEMBL5104249 | 0.75 | — | — | |
| Nitric Oxide SCHEMBL6890944 | 0.75 | — | — | |
| Nitric Oxide SCHEMBL306589 | 0.75 | — | — | |
| Nitric Oxide SCHEMBL2888647 | 0.75 | — | — | |
| Nitric Oxide SCHEMBL2890900 | 0.75 | — | — | |
| Nitric Oxide SCHEMBL3636459 | 0.75 | — | — | |
| Nitric Oxide SCHEMBL2731176 | 0.75 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 187 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12415810-B2 | 2'-isopropyl-spiro (3,3'-pyrrolidine oxindole) liver X receptor regulator, preparation method therefor, and use thereof | SHENZHEN CELL INSPIRE PHARMACEUTICAL DEVELOPMENT CO., LTD. (CN) | 2025-09-16 | — | — | US | claimed |
| EP-4578855-A1 | PROLYL HYDROXYLASE INHIBITOR AND USE THEREOF | Suzhong Pharmaceutical Group Co., Ltd. (CN) | 2025-07-02 | — | — | EP | claimed |
| EP-4570918-A1 | DUAL-LUCIFERASE REPORTER GENE DETECTION SYSTEM AND USE THEREOF | BGI Shenzhen (CN) | 2025-06-18 | — | — | EP | claimed |
| US-20250179559-A1 | DUAL-LUCIFERASE REPORTER GENE DETECTION SYSTEM, FLUORESCENCE DETECTION KIT, AND METHOD FOR DETECTING LUMINESCENT SIGNAL OF LUCIFERASE | BGI SHENZHEN (CN) | 2025-06-05 | — | — | US | claimed |
| WO-2025108404-A1 | HETEROCYCLIC COMPOUND OF BIFUNCTIONAL CHIMERA FOR TARGETED DEGRADATION OF ANDROGEN RECEPTOR AND USE THEREOF | 广东东阳光药业股份有限公司 | 2025-05-30 | — | — | WO | claimed |
| WO-2025108406-A1 | HETEROCYCLIC COMPOUND OF BIFUNCTIONAL CHIMERA FOR TARGETED DEGRADATION OF ANDROGEN RECEPTOR, AND USE THEREOF | 广东东阳光药业股份有限公司 | 2025-05-30 | — | — | WO | claimed |
| CN-120025326-A | Heterocyclic compound of bifunctional chimera for targeting and degrading androgen receptor and application thereof | 广东东阳光药业股份有限公司 | 2025-05-23 | — | — | CN | claimed |
| CN-120020129-A | Substituted nitrogen-containing bicyclic compounds and uses thereof | 广东东阳光药业股份有限公司 | 2025-05-20 | — | — | CN | claimed |
| EP-4541794-A1 | PHENYL-SUBSTITUTED DIHYDRONAPHTHYRIDINE COMPOUNDS, AND PREPARATION AND USE THEREOF | Suzhong Pharmaceutical Group Co., Ltd. (CN) | 2025-04-23 | — | — | EP | claimed |
| US-12252459-B2 | Hydrazone amide derivatives and use thereof in preparation of anti-osteoporosis drugs | SHENZHEN CELL INSPIRE PHARMACEUTICAL DEVELOPMENT CO., LTD. (CN) | 2025-03-18 | — | — | US | claimed |
| US-20220135579-A1 | 2'-ISOPROPYL-SPIRO (3,3'-PYRROLIDINE OXINDOLE) LIVER X RECEPTOR REGULATOR, PREPARATION METHOD THEREFOR, AND USE THEREOF | SHENZHEN CELL INSPIRE PHARMACEUTICAL DEVELOPMENT CO., LTD. (CN) | 2022-05-05 | — | — | US | claimed |
| EP-3992195-A1 | SPIRO (3,3'-ISOPROPYL PYRROLIDINE OXINDOLE) LIVER X RECEPTOR REGULATOR, PREPARATION METHOD THEREFOR, AND USE THEREOF | Shenzhen Cell Inspire Pharmaceutical Development Co., Ltd. (CN) | 2022-05-04 | — | — | EP | claimed |
| EP-3992184-A1 | HYDRAZONE AMIDE DERIVATIVES AND USE THEREOF IN PREPARATION OF ANTI-OSTEOPOROSIS DRUGS | Shenzhen Cell Inspire Pharmaceutical Development Co., Ltd. (CN) | 2022-05-04 | — | — | EP | claimed |
| CN-114392262-A | Betulinic acid derivatives for inhibiting nervous system degenerative diseases | 河南省生殖健康科学技术研究院(河南省出生缺陷干预工程技术研究中心) | 2022-04-26 | — | — | CN | claimed |
| CN-114344313-A | Betulinic acid derivatives for preventing or treating degenerative diseases of nervous system | 河南省科学院高新技术研究中心 | 2022-04-15 | — | — | CN | claimed |
| CN-114315952-A | Tanshinone I derivative, preparation method and application thereof | 浙江大学 | 2022-04-12 | — | — | CN | claimed |
| WO-2022067566-A1 | PYRIMIDINEDIONE COMPOUND CONTAINING SATURATED OXYGEN-CONTAINING HETEROCYCLIC GROUP AND USE THEREOF | 广东东阳光药业有限公司 | 2022-04-07 | — | — | WO | claimed |
| WO-2022067573-A1 | SULFONAMIDE-SUBSTITUTED HETEROARYL PYRIMIDINEDIONE COMPOUND AND USE THEREOF | 广东东阳光药业有限公司 | 2022-04-07 | — | — | WO | claimed |
| WO-2022037560-A1 | PYRIMIDONE DERIVATIVE AND APPLICATION THEREOF IN DRUG | 广东东阳光药业有限公司 | 2022-02-24 | — | — | WO | claimed |
| WO-2009043108-A1 | REMOVAL OF POLLUTANTS FROM A GAS FLOW | INDIGO TECHNOLOGIES GROUP PTY LTD (AU) | 2009-04-09 | — | — | WO | claimed |