Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 6/20 | 0.68 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.60 |
| ▸ | DRD1 | P21728 | 1/20 | 0.60 |
| ▸ | LMNA | P02545 | 3/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.56 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.56 |
| ▸ | DHFR | P00374 | 1/20 | 0.52 |
| ▸ | TOP2A | P11388 | 4/20 | 0.50 |
| ▸ | TOP2B | Q02880 | 4/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.50 |
| ▸ | ATP6V1B2 | P21281 | 1/20 | 0.50 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.50 |
| ▸ | EDNRA | P25101 | 1/20 | 0.50 |
| ▸ | TARBP2 | Q15633 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10377708 | 0.89 | DPP4 (0.66) | DPP4CHRM2DRD1LMNAKDM4E | |
| SCHEMBL10377337 | 0.88 | DPP4 (0.65) | DPP4CHRM2DRD1LMNAKDM4E | |
| SCHEMBL10377719 | 0.88 | DPP4 (0.65) | DPP4CHRM2DRD1LMNAKDM4E | |
| SCHEMBL9757404 | 0.87 | DPP4 (0.69) | DPP4CHRM2DRD1LMNAKDM4E | |
| SCHEMBL10874660 | 0.87 | DPP4 (0.63) | DPP4CHRM2DRD1LMNAKDM4E | |
| SCHEMBL10377610 | 0.86 | DPP4 (0.62) | DPP4CHRM2DRD1LMNAKDM4E | |
| SCHEMBL11022634 | 0.86 | DPP4 (0.68) | DPP4CHRM2DRD1LMNAKDM4E | |
| SCHEMBL10377621 | 0.86 | DPP4 (0.62) | DPP4CHRM2DRD1LMNAKDM4E | |
| SCHEMBL9522864 | 0.86 | DPP4 (0.68) | DPP4CHRM2DRD1LMNAKDM4E | |
| SCHEMBL311935 | 0.86 | LMNA (0.68) | DPP4CHRM2DRD1LMNAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7902227-B2 | C-7 isoxazolinyl quinolone / naphthyridine derivatives useful as antibacterial agents | JANSSEN PHARMACEUTICA NV. (BE) | 2011-03-08 | — | — | US | disclosed |
| US-7902227-B2 | C-7 isoxazolinyl quinolone / naphthyridine derivatives useful as antibacterial agents | JANSSEN PHARMACEUTICA NV. (BE) | 2011-03-08 | — | — | US | disclosed |
| US-7902227-B2 | C-7 isoxazolinyl quinolone / naphthyridine derivatives useful as antibacterial agents | JANSSEN PHARMACEUTICA NV. (BE) | 2011-03-08 | — | — | US | disclosed |
| WO-2010093341-A1 | C-7 ISOXAZOLINYL QUINOLONE/NAPHTHYRIDINE DERIVATIVES USEFUL AS ANTIBACTERIAL AGENTS | JANSSEN PHARMACEUTICA N.V. (BE) | 2010-08-19 | — | — | WO | disclosed |
| US-20090029980-A1 | C-7 Isoxazolinyl Quinolone / Naphthyridine Derivatives Useful as Antibacterial Agents | JANSSEN PHARMACEUTICA N.V. (BE) | 2009-01-29 | — | — | US | disclosed |
| US-20090029980-A1 | C-7 Isoxazolinyl Quinolone / Naphthyridine Derivatives Useful as Antibacterial Agents | JANSSEN PHARMACEUTICA N.V. (BE) | 2009-01-29 | — | — | US | disclosed |
| US-20090029980-A1 | C-7 Isoxazolinyl Quinolone / Naphthyridine Derivatives Useful as Antibacterial Agents | JANSSEN PHARMACEUTICA N.V. (BE) | 2009-01-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090029980-A1 | C-7 Isoxazolinyl Quinolone / Naphthyridine Derivatives Useful as Antibacterial Agents | CASP7, CYP3A7, NQO2 | DPP4 491/4885CHRM2 4648/4885DRD1 1223/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.