Chloroxine

Chloroxine

SCHEMBL4249557

C=C(C)C(=O)O.Oc1c(Cl)cc(Cl)c2cccnc12

nearest known ligand 0.72

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALOX12 P18054 8/20 0.72
HSP90AA1 P07900 5/20 0.72
KDM4E B2RXH2 5/20 0.72
MAPT P10636 5/20 0.72
HTT P42858 5/20 0.72
SMN1; SMN2 Q16637 5/20 0.72
MEN1 O00255 4/20 0.72
KMT2A Q03164 4/20 0.72
TDP1 Q9NUW8 4/20 0.72
ALDH1A1 P00352 4/20 0.72
LMNA P02545 4/20 0.72
MMP14 P50281 3/20 0.72
OPRK1 P41145 3/20 0.72
TP53 P04637 2/20 0.72
CYP3A4 P08684 2/20 0.72
ALOX15 P16050 2/20 0.72
SLC6A2 P23975 2/20 0.72
ALOX15B O15296 1/20 0.72
NR1I2 O75469 1/20 0.72
HTR1A P08908 1/20 0.72

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Chloroxine SCHEMBL4459987 0.91 ALOX12 (0.81) ALOX12HSP90AA1KDM4EMAPTHTT
Chloroxine SCHEMBL29389908 0.85 KDM4E (1.00) ALOX12HSP90AA1KDM4EMAPTHTT
Chloroxine SCHEMBL3350 0.85 KDM4E (1.00) ALOX12HSP90AA1KDM4EMAPTHTT
Chloroxine SCHEMBL29399997 0.85 KDM4E (1.00) ALOX12HSP90AA1KDM4EMAPTHTT
Chloroxine SCHEMBL231205 0.83 KDM4E (0.96) ALOX12HSP90AA1KDM4EMAPTHTT
Chloroxine SCHEMBL6677225 0.83 KDM4E (0.96) ALOX12HSP90AA1KDM4EMAPTHTT
Chloroxine SCHEMBL4297732 0.83 KDM4E (0.96) ALOX12HSP90AA1KDM4EMAPTHTT
Chloroxine SCHEMBL9135479 0.83 KDM4E (0.96) ALOX12HSP90AA1KDM4EMAPTHTT
Chloroxine SCHEMBL22734873 0.83 KDM4E (0.96) ALOX12HSP90AA1KDM4EMAPTHTT
Chloroxine SCHEMBL4293183 0.83 KDM4E (0.96) ALOX12HSP90AA1KDM4EMAPTHTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7632630-B2 Dyed photoresists and methods and articles of manufacture comprising same ROHM AND HAAS ELECTRONIC MATERIALS LLC (US) 2009-12-15 US disclosed
US-20090220888-A1 Dyed photoresists and methods and articles of manufacture comprising same SHIPLEY COMPANY, L.L.C. (US) 2009-09-03 US disclosed
US-7147983-B1 Dyed photoresists and methods and articles of manufacture comprising same SHIPLEY COMPANY, L.L.C. (US) 2006-12-12 US disclosed
US-20060204892-A1 Dyed photoresists and methods and articles of manufacture comprising same SHIPLEY (US) 2006-09-14 US disclosed
EP-0813114-B1 Antireflective coating compositions SHIPLEY CO LLC (US) 2004-02-18 EP disclosed
EP-0834770-B1 Dyed photoresists and methods and articles of manufacture comprising same SHIPLEY CO LLC (US) 2003-11-26 EP disclosed
US-6033830-A Antireflective coating compositions SHIPLEY COMPANY, L.L.C. (US) 2000-03-07 US disclosed
US-5886102-A Antireflective coating compositions SHIPLEY COMPANY, L.L.C. (US) 1999-03-23 US disclosed
EP-0834770-A2 Dyed photoresists and methods and articles of manufacture comprising same Shipley Company LLC (US) 1998-04-08 EP disclosed
EP-0813114-A2 Antireflective coating compositions Shipley Company LLC (US) 1997-12-17 EP disclosed