Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GNAO1 | P09471 | 9/20 | 0.96 |
| ▸ | GNAI3 | P08754 | 8/20 | 0.96 |
| ▸ | GNAI1 | P63096 | 8/20 | 0.96 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.63 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.50 |
| ▸ | BCHE | P06276 | 1/20 | 0.46 |
| ▸ | EBP | Q15125 | 1/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.46 |
| ▸ | GUSB | P08236 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5852136 | 1.00 | GNAO1 (0.96) | GNAO1GNAI3GNAI1SPHK1KCNH2 | |
| SCHEMBL19779489 | 1.00 | GNAO1 (0.96) | GNAO1GNAI3GNAI1SPHK1KCNH2 | |
| SCHEMBL595977 | 0.98 | GNAO1 (0.92) | GNAO1GNAI3GNAI1SPHK1KCNH2 | |
| Dimethylamine SCHEMBL6943083 | 0.92 | GNAO1 (0.82) | GNAO1GNAI3GNAI1SPHK1KCNH2 | |
| SCHEMBL6941884 | 0.91 | GNAO1 (0.81) | GNAO1GNAI3GNAI1SPHK1KCNH2 | |
| Hydrochloric Acid SCHEMBL9481013 | 0.89 | GNAO1 (0.85) | GNAO1GNAI3GNAI1SPHK1KCNH2 | |
| Diethylamine SCHEMBL6941583 | 0.89 | GNAO1 (0.77) | GNAO1GNAI3GNAI1SPHK1KCNH2 | |
| SCHEMBL24261282 | 0.88 | GNAO1 (0.76) | GNAO1GNAI3GNAI1SPHK1BCHE | |
| SCHEMBL22778650 | 0.88 | GNAO1 (0.76) | GNAO1GNAI3GNAI1SPHK1BCHE | |
| SCHEMBL24753537 | 0.88 | GNAO1 (0.76) | GNAO1GNAI3GNAI1SPHK1BCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104449906-B | Reduce the granular material discharged additive of alcohol-group fuel | SHANXI HUADUN INDUSTRY CO., LTD. (CN) | 2016-05-04 | — | — | CN | claimed |
| CN-107567445-B | 2-phenyl-3H-imidazo [4,5-B ] pyridine derivatives useful as inhibitors of mammalian tyrosine kinase ROR1 activity | 坎塞拉有限公司 | 2021-06-29 | — | — | CN | disclosed |
| EP-3253754-B1 | 2-PHENYL-3H-IMIDAZO[4,5-B]PYRIDINE DERIVATES USEFUL AS INHIBITORS OF MAMMALIAN TYROSINE KINASE ROR1 ACTIVITY | KANCERA AB (SE) | 2021-03-31 | — | — | EP | disclosed |
| US-10550113-B2 | 2-phenyl-3H-imidazo[4,5-B]pyridine derivates useful as inhibitors of mammalian tyrosine kinase ROR1 activity | KANCERA AB (SE) | 2020-02-04 | — | — | US | disclosed |
| CN-107567445-A | It can be used as 2 phenyl 3H imidazos [4,5 B] pyridine derivates of mammal EGFR-TK ROR1 activities inhibitor | 坎塞拉有限公司 | 2018-01-09 | — | — | CN | disclosed |
| US-20180002329-A1 | 2-PHENYL-3H-IMIDAZO[4,5-B]PYRIDINE DERIVATES USEFUL AS INHIBITORS OF MAMMALIAN TYROSINE KINASE ROR1 ACTIVITY | KANCERA AB (SE) | 2018-01-04 | — | — | US | disclosed |
| WO-2017197051-A1 | AMINE-LINKED C3-GLUTARIMIDE DEGRONIMERS FOR TARGET PROTEIN DEGRADATION | C4 THERAPEUTICS, INC. (US) | 2017-11-16 | — | — | WO | disclosed |
| WO-2016124553-A1 | 2-PHENYL-3H-IMIDAZO[4,5-B]PYRIDINE DERIVATES USEFUL AS INHIBITORS OF MAMMALIAN TYROSINE KINASE ROR1 ACTIVITY | KANCERA AB (SE) | 2016-08-11 | — | — | WO | disclosed |
| CN-104449906-B | Reduce the granular material discharged additive of alcohol-group fuel | SHANXI HUADUN INDUSTRY CO., LTD. (CN) | 2016-05-04 | — | — | CN | disclosed |
| CN-104449906-B | Reduce the granular material discharged additive of alcohol-group fuel | SHANXI HUADUN INDUSTRY CO., LTD. (CN) | 2016-05-04 | — | — | CN | disclosed |
| CN-103764648-B | Pyrrolidin-3-yl acetic acid derivatives | EISAI R&D MAN CO LTD | 2015-07-01 | — | — | CN | disclosed |
| EP-2757103-A1 | PYRROLIDINE-3-YLACETIC ACID DERIVATIVE | Eisai R&D Management Co., Ltd. (JP) | 2014-07-23 | — | — | EP | disclosed |
| CN-103764648-A | Pyrrolidin-3-yl acetic acid derivatives | EISAI R&D MAN CO LTD | 2014-04-30 | — | — | CN | disclosed |
| US-8476301-B2 | Pyrrolidin-3-ylacetic acid derivative | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2013-07-02 | — | — | US | disclosed |
| US-20130065925-A1 | PYRROLIDIN-3-YLACETIC ACID DERIVATIVE | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2013-03-14 | — | — | US | disclosed |
| WO-2009041789-A2 | NOVEL 3-CHLORO-5-SUBSTITUTED-QUINOXALINE-2-AMINE DERIVATIVES AND PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, METHOD FOR PREPARATION, THERAPEUTIC AGENT FOR INFLAMMATORY DISEASE INDUCED BY SPC ACTIVITY CONTAINING 3-CHLORO-5-SUBSTITUTED-QUINOXALINE-2-AMINE DERIVATIVES AS AN EFFECTIVE INGREDIENT | KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) | 2009-04-02 | — | — | WO | disclosed |
| US-6921821-B2 | Antagonists of melanin concentrating hormone receptor | ABBOTT LABORATORIES (US) | 2005-07-26 | — | — | US | disclosed |
| EP-1534703-A2 | ANTAGONISTS OF MELANIN CONCENTRATING HORMONE RECEPTOR | ABBOTT LABORATORIES (US) | 2005-06-01 | — | — | EP | disclosed |
| US-20040106645-A1 | Antagonists of melanin concentrating hormone receptor | MILLENNIUM PHARMACEUTICALS, INC. | 2004-06-03 | — | — | US | disclosed |
| WO-2003106452-A2 | ANTAGONISTS OF MELANIN CONCENTRATING HORMONE RECEPTOR | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2003-12-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10550113-B2 | 2-phenyl-3H-imidazo[4,5-B]pyridine derivates useful as inhibitors of mammalian tyrosine kinase ROR1 activity | ROR1, RORB, RORA | GNAO1 599/4885GNAI3 158/4885GNAI1 50/4885 |
| US-20040106645-A1 | Antagonists of melanin concentrating hormone receptor | MCHR1, MCHR2, MC1R | GNAO1 752/4885GNAI3 2191/4885GNAI1 1586/4885 |
| US-20130065925-A1 | PYRROLIDIN-3-YLACETIC ACID DERIVATIVE | CX3CR1, CCR2, CCL2 | GNAO1 2056/4885GNAI3 1518/4885GNAI1 1437/4885 |
| US-20180002329-A1 | 2-PHENYL-3H-IMIDAZO[4,5-B]PYRIDINE DERIVATES USEFUL AS INHIBITORS OF MAMMALIAN TYROSINE KINASE ROR1 ACTIVITY | ROR1, RORB, RORA | GNAO1 599/4885GNAI3 158/4885GNAI1 50/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.