Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 5/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | MMP13 | P45452 | 4/20 | 0.41 |
| ▸ | BCHE | P06276 | 1/20 | 0.40 |
| ▸ | MMP2 | P08253 | 1/20 | 0.40 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.39 |
| ▸ | LTA4H | P09960 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | EPOR | P19235 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL893517 | 0.90 | CYP3A4 (0.48) | ALOX5PTGS1PTGS2L3MBTL1MMP13 | |
| SCHEMBL4252383 | 0.88 | TSHR (0.43) | ALOX5L3MBTL1 | |
| SCHEMBL4251210 | 0.83 | CYP3A4 (0.51) | ALOX5PTGS1PTGS2L3MBTL1MMP13 | |
| SCHEMBL893518 | 0.81 | CYP3A4 (0.53) | ALOX5PTGS1PTGS2L3MBTL1MMP13 | |
| SCHEMBL893181 | 0.81 | L3MBTL1 (0.44) | L3MBTL1 | |
| SCHEMBL4390635 | 0.79 | ACHE (0.39) | L3MBTL1BCHE | |
| SCHEMBL893827 | 0.79 | CYP3A4 (0.48) | PARP10 | |
| SCHEMBL23120532 | 0.75 | LTA4H (0.64) | ALOX5PTGS1PTGS2L3MBTL1BCHE | |
| SCHEMBL4248044 | 0.73 | CYP3A4 (0.57) | — | |
| SCHEMBL23120176 | 0.72 | ALOX5 (0.56) | ALOX5PTGS1PTGS2L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2081917-A2 | CYTOCHROME P450 OXIDASE INHIBITORS AND USES THEREOF | Abbott Laboratories (US) | 2009-07-29 | — | — | EP | claimed |
| WO-2008027932-A2 | CYTOCHROME P450 OXIDASE INHIBITORS AND USES THEREOF | ABBOTT LABORATORIES (US) | 2008-03-06 | — | — | WO | claimed |