Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FYN | P06241 | 14/20 | 0.41 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.40 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.35 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
| ▸ | TYR | P14679 | 1/20 | 0.35 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.34 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.34 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22095365 | 0.82 | KEAP1 (0.46) | FYNTGFBR1CHEK1CHEK2ABL1 | |
| SCHEMBL4253252 | 0.79 | FYN (0.40) | FYNCHEK1CHEK2ABL1TYR | |
| SCHEMBL4258498 | 0.79 | FYN (0.40) | FYNCHEK1CHEK2ABL1TYR | |
| SCHEMBL18041661 | 0.72 | PIK3CA (0.47) | TGFBR1 | |
| SCHEMBL31251397 | 0.70 | ADORA3 (0.47) | FYNCHEK1CHEK2ABL1TYR | |
| SCHEMBL22095679 | 0.68 | FLT3 (0.41) | TGFBR1 | |
| SCHEMBL4249759 | 0.68 | DYRK1A (0.38) | TGFBR1 | |
| SCHEMBL2255937 | 0.67 | ACVRL1 (0.44) | CHEK1 | |
| SCHEMBL22095711 | 0.67 | LDHA (0.33) | TGFBR1 | |
| SCHEMBL13873982 | 0.66 | FYN (0.55) | FYNCHEK1CHEK2ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090215818-A1 | THIOZOLIDINEDIONE DERIVATIVES AS PI3 KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-08-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090215818-A1 | THIOZOLIDINEDIONE DERIVATIVES AS PI3 KINASE INHIBITORS | PIK3CD, PI4KA, PIP4K2A | FYN 115/4885TGFBR1 444/4885CHEK1 553/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.