Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | HTR1A | P08908 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 4/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | ESR1 | P03372 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4260752 | 0.87 | ESR1 (0.52) | ALDH1A1MEN1KMT2AESR1GAA | |
| SCHEMBL4254583 | 0.87 | MEN1 (0.52) | ALDH1A1MEN1KMT2AESR1HSD17B10 | |
| SCHEMBL4256269 | 0.86 | NR1H3 (0.52) | MEN1KMT2AMCHR1HTT | |
| SCHEMBL4250037 | 0.86 | CYP3A4 (0.50) | ALDH1A1MEN1KMT2AESR1MCHR1 | |
| SCHEMBL4253067 | 0.86 | ESR1 (0.52) | ALDH1A1MEN1KMT2AESR1MCHR1 | |
| SCHEMBL4259106 | 0.86 | CYP3A4 (0.43) | ALDH1A1MEN1KMT2AESR1MCHR1 | |
| SCHEMBL4254027 | 0.80 | ALDH1A1 (0.66) | ALDH1A1MEN1KMT2AESR1KDM4E | |
| SCHEMBL4250774 | 0.75 | NR1H3 (0.56) | ALDH1A1MEN1KMT2AMCHR1HTT | |
| SCHEMBL4258439 | 0.75 | ESR1 (0.61) | ALDH1A1MEN1KMT2AESR1KDM4E | |
| SCHEMBL10485708 | 0.74 | APP (0.53) | ALDH1A1MEN1KMT2AKDM4EGLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009054653-A2 | ISOINDOLONES WITH HIGH BINDING AFFINITY TO BETA-AMYLOID AGGREGATES AND FIBRILS, AND ITS USE AND PREPARATION METHOD | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2009-04-30 | — | — | WO | claimed |
| WO-2009054653-A2 | ISOINDOLONES WITH HIGH BINDING AFFINITY TO BETA-AMYLOID AGGREGATES AND FIBRILS, AND ITS USE AND PREPARATION METHOD | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2009-04-30 | — | — | WO | disclosed |