Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 3/20 | 0.52 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.52 |
| ▸ | STAT3 | P40763 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.44 |
| ▸ | MEN1 | O00255 | 4/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4253697 | 0.86 | ALDH1A1 (0.50) | ESR1KMT2AMEN1HTTALDH1A1 | |
| SCHEMBL4260752 | 0.86 | ESR1 (0.52) | ESR1KMT2AMEN1HTTALDH1A1 | |
| SCHEMBL4254583 | 0.86 | MEN1 (0.52) | ESR1KMT2AMEN1HTTALDH1A1 | |
| SCHEMBL4256269 | 0.85 | NR1H3 (0.52) | KMT2AMEN1HTTMCHR1 | |
| SCHEMBL4250037 | 0.85 | CYP3A4 (0.50) | ESR1KMT2AMEN1HTTALDH1A1 | |
| SCHEMBL4259106 | 0.85 | CYP3A4 (0.43) | ESR1KMT2AMEN1HTTALDH1A1 | |
| SCHEMBL4256261 | 0.78 | HTR2C (0.44) | MCHR1POLBRAB9A | |
| SCHEMBL4249698 | 0.76 | ESR1 (0.67) | ESR1ESR2STAT3NPSR1KMT2A | |
| SCHEMBL19317171 | 0.76 | ESR1 (0.73) | ESR1ESR2STAT3NPSR1KMT2A | |
| SCHEMBL18641055 | 0.75 | APP (0.51) | POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009054653-A2 | ISOINDOLONES WITH HIGH BINDING AFFINITY TO BETA-AMYLOID AGGREGATES AND FIBRILS, AND ITS USE AND PREPARATION METHOD | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2009-04-30 | — | — | WO | claimed |
| WO-2009054653-A2 | ISOINDOLONES WITH HIGH BINDING AFFINITY TO BETA-AMYLOID AGGREGATES AND FIBRILS, AND ITS USE AND PREPARATION METHOD | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2009-04-30 | — | — | WO | disclosed |