Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 5/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | ESR1 | P03372 | 1/20 | 0.42 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.41 |
| ▸ | AR | P10275 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.40 |
| ▸ | CASP3 | P42574 | 1/20 | 0.39 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4260752 | 0.86 | ESR1 (0.52) | MEN1KMT2AHTTALDH1A1MAPT | |
| SCHEMBL4254583 | 0.86 | MEN1 (0.52) | MEN1KMT2AHTTALDH1A1ESR1 | |
| SCHEMBL4253697 | 0.86 | ALDH1A1 (0.50) | MEN1KMT2AHTTALDH1A1MAPT | |
| SCHEMBL4256269 | 0.85 | NR1H3 (0.52) | MEN1KMT2AHTTMCHR1GRM1 | |
| SCHEMBL17326663 | 0.85 | MEN1 (0.53) | MEN1KMT2AHTTALDH1A1MAPT | |
| SCHEMBL4259106 | 0.85 | CYP3A4 (0.43) | CYP3A4MEN1KMT2AHTTALDH1A1 | |
| SCHEMBL4253067 | 0.85 | ESR1 (0.52) | MEN1KMT2AHTTALDH1A1MAPT | |
| SCHEMBL4253350 | 0.78 | NPC1 (0.48) | CYP3A4MAPTMCHR1RAB9A | |
| SCHEMBL4249678 | 0.78 | CYP3A4 (0.47) | CYP3A4MCHR1RAB9A | |
| SCHEMBL4256208 | 0.76 | ALDH1A1 (0.50) | MEN1KMT2AALDH1A1MAPTESR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009054653-A2 | ISOINDOLONES WITH HIGH BINDING AFFINITY TO BETA-AMYLOID AGGREGATES AND FIBRILS, AND ITS USE AND PREPARATION METHOD | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2009-04-30 | — | — | WO | claimed |