Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 3/20 | 0.59 |
| ▸ | CES2 | O00748 | 1/20 | 0.59 |
| ▸ | POLB | P06746 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | USP19 | O94966 | 1/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.37 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | LCK | P06239 | 1/20 | 0.36 |
| ▸ | HCK | P08631 | 1/20 | 0.36 |
| ▸ | SRC | P12931 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.36 |
| ▸ | MGLL | Q99685 | 2/20 | 0.36 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL445164 | 0.99 | FAAH (0.58) | FAAHCES2POLBRAB9AATM | |
| SCHEMBL15559209 | 0.91 | FAAH (0.59) | FAAHCES2POLBRAB9AATM | |
| SCHEMBL428300 | 0.85 | F10 (0.45) | FAAHCES2POLBALDH1A1 | |
| SCHEMBL427256 | 0.84 | FAAH (0.65) | FAAHCES2POLBRAB9AUSP19 | |
| SCHEMBL427164 | 0.83 | FAAH (0.66) | FAAHCES2POLBRAB9AUSP19 | |
| SCHEMBL424383 | 0.82 | FAAH (0.74) | FAAHCES2POLBRAB9AATM | |
| SCHEMBL425885 | 0.82 | FAAH (0.63) | FAAHCES2RAB9AUSP19HDAC6 | |
| SCHEMBL428043 | 0.81 | FAAH (0.51) | FAAHCES2POLBHTTKDM4E | |
| SCHEMBL15554007 | 0.81 | FAAH (0.64) | FAAHCES2POLBRAB9AUSP19 | |
| SCHEMBL424585 | 0.81 | FAAH (0.67) | FAAHCES2POLBRAB9AATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11046654-B2 | Urea compounds and their use as enzyme inhibitors | BIAL-PORTELA & CA, S.A. (PT) | 2021-06-29 | — | — | US | disclosed |
| US-20190135764-A1 | UREA COMPOUNDS AND THEIR USE AS ENZYME INHIBITORS | BIAL-PORTELA & CA, S.A. (PT) | 2019-05-09 | — | — | US | disclosed |
| US-10023541-B2 | Urea compounds and their use as enzyme inhibitors | BIAL-PORTELA & CA, S.A. (PT) | 2018-07-17 | — | — | US | disclosed |
| EP-2890684-B1 | UREA COMPOUNDS AND THEIR USE AS ENZYME INHIBITORS | BIAL-PORTELA & CA S A (PT) | 2018-02-14 | — | — | EP | disclosed |
| US-20170101381-A1 | UREA COMPOUNDS AND THEIR USE AS ENZYME INHIBITORS | BIAL-PORTELA & CA, S.A. (PT) | 2017-04-13 | — | — | US | disclosed |
| US-9549915-B2 | Urea compounds and their use as enzyme inhibitors | BIAL-PORTELA & CA, S.A. (PT) | 2017-01-24 | — | — | US | disclosed |
| US-9353082-B2 | Pharmaceutical compounds | BIAL—PORTELA & CA, S.A. (PT) | 2016-05-31 | — | — | US | disclosed |
| US-9353082-B2 | Pharmaceutical compounds | BIAL—PORTELA & CA, S.A. (PT) | 2016-05-31 | — | — | US | disclosed |
| EP-2890684-A2 | UREA COMPOUNDS AND THEIR USE AS ENZYME INHIBITORS | Bial-Portela & CA, S.A. (PT) | 2015-07-08 | — | — | EP | disclosed |
| US-20150174103-A1 | UREA COMPOUNDS AND THEIR USE AS ENZYME INHIBITORS | BIAL-PORTELA & CA, S.A. (PT) | 2015-06-25 | — | — | US | disclosed |
| WO-2014017936-A2 | UREA COMPOUNDS AND THEIR USE AS ENZYME INHIBITORS | BIAL- PORTELA & CA, S.A. (PT) | 2014-01-30 | — | — | WO | disclosed |
| US-20120065191-A1 | PHARMACEUTICAL COMPOUNDS | BIAL - PORTELA & Cª, S.A. (PT) | 2012-03-15 | — | — | US | disclosed |
| US-20120065191-A1 | PHARMACEUTICAL COMPOUNDS | BIAL - PORTELA & Cª, S.A. (PT) | 2012-03-15 | — | — | US | disclosed |
| WO-2010074588-A2 | PHARMACEUTICAL COMPOUNDS | BIAL - PORTELA & Cª, S.A. (PT) | 2010-07-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11046654-B2 | Urea compounds and their use as enzyme inhibitors | ACHE, GAA, GYS2 | FAAH 281/4885CES2 5/4885POLB 1423/4885 |
| US-10023541-B2 | Urea compounds and their use as enzyme inhibitors | ACHE, GAA, GYS2 | FAAH 281/4885CES2 5/4885POLB 1423/4885 |
| US-20190135764-A1 | UREA COMPOUNDS AND THEIR USE AS ENZYME INHIBITORS | ACHE, GAA, GYS2 | FAAH 281/4885CES2 5/4885POLB 1423/4885 |
| US-20170101381-A1 | UREA COMPOUNDS AND THEIR USE AS ENZYME INHIBITORS | ACHE, GAA, GYS2 | FAAH 281/4885CES2 5/4885POLB 1423/4885 |
| US-20120065191-A1 | PHARMACEUTICAL COMPOUNDS | FAAH, FAAH2, ASAH1 | FAAH 1/4885CES2 62/4885POLB 2792/4885 |
| US-20150174103-A1 | UREA COMPOUNDS AND THEIR USE AS ENZYME INHIBITORS | ACHE, GAA, GYS2 | FAAH 281/4885CES2 5/4885POLB 1423/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.