SCHEMBL4254650

SCHEMBL4254650

O=C(O)c1oc2ccccc2c(=O)c1[N+](=O)[O-]

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 7/20 0.50
ALDH1A1 P00352 6/20 0.48
PKM P14618 2/20 0.48
HTT P42858 1/20 0.48
MAPT P10636 6/20 0.47
TTR P02766 2/20 0.47
KDM4E B2RXH2 3/20 0.46
CYP3A4 P08684 2/20 0.46
HPGD P15428 2/20 0.46
MAOA P21397 2/20 0.46
GLA P06280 1/20 0.46
PGAM1 P18669 1/20 0.46
CASP1 P29466 1/20 0.46
CASP7 P55210 1/20 0.46
SMN1; SMN2 Q16637 1/20 0.46
HSD17B10 Q99714 1/20 0.46
KMT2A Q03164 3/20 0.45
MEN1 O00255 2/20 0.45
CA12 O43570 1/20 0.45
CA1 P00915 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12481401 0.89 LMNA (0.50) LMNAALDH1A1PKMHTTMAPT
SCHEMBL9061230 0.78 LMNA (0.51) LMNAALDH1A1PKMHTTMAPT
SCHEMBL1457741 0.77 LMNA (0.58) LMNAALDH1A1PKMHTTMAPT
SCHEMBL10719512 0.76 LMNA (0.54) LMNAALDH1A1PKMHTTMAPT
SCHEMBL752884 0.76 KDM4E (0.65) LMNAALDH1A1PKMHTTMAPT
SCHEMBL11360558 0.76 KDM4E (0.53) LMNAALDH1A1PKMHTTMAPT
SCHEMBL29587413 0.74 TTR (0.52) LMNAALDH1A1PKMHTTMAPT
SCHEMBL7092243 0.74 MAOA (0.52) LMNAALDH1A1PKMMAPTTTR
SCHEMBL6045428 0.74 TTR (0.52) LMNAALDH1A1PKMHTTMAPT
SCHEMBL28807954 0.74 GPR35 (0.45) MAPTSMN1; SMN2KMT2AMEN1GAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2105431-A1 Process for Producing Chromone Compound Sumitomo Chemical Company, Limited (JP) 2009-09-30 EP disclosed
EP-2105432-A1 Process for Producing Chromone Compound Sumitomo Chemical Company, Limited (JP) 2009-09-30 EP disclosed
EP-1867626-A2 Process for producing chromone compound Sumitomo Chemical Company, Limited (JP) 2007-12-19 EP disclosed
US-20060217565-A1 Process for producing chromone compound SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2006-09-28 US disclosed
US-7094914-B2 Process for producing chromone compound SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2006-08-22 US disclosed
US-20050085664-A1 Process for producing chromone compound SUMITOMO CHEMICAL COMPANY, LMITED (JP) 2005-04-21 US disclosed
EP-1479667-A1 PROCESS FOR PRODUCING CHROMONE COMPOUND Sumitomo Chemical Company, Limited (JP) 2004-11-24 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050085664-A1 Process for producing chromone compound ENY2, CDY1; CDY1B, CDYL LMNA 1091/4885ALDH1A1 3157/4885PKM 744/4885
US-20060217565-A1 Process for producing chromone compound ENY2, CDY1; CDY1B, CDYL LMNA 1091/4885ALDH1A1 3157/4885PKM 744/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.