Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP12 | P39900 | 5/20 | 0.47 |
| ▸ | MMP13 | P45452 | 4/20 | 0.47 |
| ▸ | MMP2 | P08253 | 1/20 | 0.47 |
| ▸ | MMP9 | P14780 | 1/20 | 0.47 |
| ▸ | MMP14 | P50281 | 1/20 | 0.47 |
| ▸ | DPP4 | P27487 | 1/20 | 0.44 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.44 |
| ▸ | PTGFR | P43088 | 1/20 | 0.44 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | DHFR | P00374 | 1/20 | 0.40 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4799370 | 0.84 | MMP2 (0.55) | MMP12MMP13MMP2MMP9MMP14 | |
| SCHEMBL28743244 | 0.78 | MAOA (0.52) | — | |
| SCHEMBL4256995 | 0.77 | LTB4R (0.53) | PTGER1PTGFRPTGER2 | |
| SCHEMBL18063343 | 0.77 | TDP1 (0.51) | MMP12MMP13MMP2MMP9MMP14 | |
| SCHEMBL18063390 | 0.76 | PTGFR (0.49) | MMP12MMP13MMP2MMP9MMP14 | |
| SCHEMBL2921490 | 0.76 | TRPA1 (0.53) | MMP12MMP13MMP2MMP9MMP14 | |
| SCHEMBL18863862 | 0.76 | TDP1 (0.56) | MMP12MMP13MMP2MMP9MMP14 | |
| SCHEMBL31354792 | 0.76 | LTB4R (0.52) | PTGER1PTGFRPTGER2 | |
| SCHEMBL26970639 | 0.76 | MAOA (0.50) | — | |
| SCHEMBL14968476 | 0.75 | TSHR (0.49) | MMP12MMP13MMP2MMP9MMP14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090035279-A1 | GENETIC VARIANTS ON CHR 15Q24 AS MARKERS FOR USE IN DIAGNOSIS, PROGNOSIS AND TREATMENT OF EXFOLIATION SYNDROME AND GLAUCOMA | DECODE GENETICS EFH (IS) | 2009-02-05 | — | — | US | disclosed |