Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.45 |
| ▸ | USP2 | O75604 | 4/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.43 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4257512 | 0.89 | LMNA (0.48) | SMN1; SMN2HSD17B10CYP2D6MEN1KMT2A | |
| SCHEMBL4258569 | 0.85 | MMP1 (0.43) | POLBCYP3A4CYP2D6CYP2C9GRM2 | |
| SCHEMBL4271922 | 0.84 | GRM2 (0.38) | TSHRHSD17B10POLBCYP3A4CYP2D6 | |
| SCHEMBL4266283 | 0.83 | ALDH1A1 (0.43) | HSD17B10CYP3A4CYP2D6USP2CYP2C9 | |
| SCHEMBL4265584 | 0.81 | GRM2 (0.43) | GRM2MEN1KMT2A | |
| SCHEMBL4258709 | 0.80 | LMNA (0.46) | TSHRSMN1; SMN2CYP3A4CYP2D6USP2 | |
| SCHEMBL4263517 | 0.77 | MAPK1 (0.37) | TSHRSMN1; SMN2HSD17B10KDM4ECYP3A4 | |
| SCHEMBL1085778 | 0.77 | CYP3A4 (0.48) | TSHRSMN1; SMN2HSD17B10CYP3A4CYP2D6 | |
| SCHEMBL4262418 | 0.76 | MEN1 (0.41) | SMN1; SMN2MEN1KMT2A | |
| SCHEMBL5013591 | 0.76 | TSHR (0.47) | TSHRSMN1; SMN2HSD17B10KDM4EPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1910381-B1 | SUBSTITUTED 1-OXA-3,8-DIAZASPIRO[4.5]-DECAN-2-ON- COMPOUNDS AND THE USE THEREOF FOR PRODUCING DRUGS | GRUENENTHAL GMBH (DE) | 2009-06-03 | — | — | EP | claimed |
| EP-1910381-B1 | SUBSTITUTED 1-OXA-3,8-DIAZASPIRO[4.5]-DECAN-2-ON- COMPOUNDS AND THE USE THEREOF FOR PRODUCING DRUGS | GRUENENTHAL GMBH (DE) | 2009-06-03 | — | — | EP | disclosed |