SCHEMBL4258569

SCHEMBL4258569

COc1ccc(NC(=O)ON2CCC3(CC2)CN(Cc2ccc4ccccc4c2)C(=O)O3)cc1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MMP1 P03956 1/20 0.43
MMP9 P14780 1/20 0.43
MMP13 P45452 1/20 0.43
ADAM17 P78536 1/20 0.43
FAAH O00519 5/20 0.42
MCHR1 Q99705 6/20 0.41
DRD4 P21917 1/20 0.40
NPC1 O15118 1/20 0.39
CASP3 P42574 1/20 0.39
RAB9A P51151 1/20 0.39
SENP7 Q9BQF6 1/20 0.39
LMNA P02545 1/20 0.39
POLB P06746 1/20 0.39
PPARG P37231 1/20 0.39
NCOA2 Q15596 1/20 0.39
NCOA1 Q15788 1/20 0.39
CTDSP1 Q9GZU7 1/20 0.39
NCOA3 Q9Y6Q9 1/20 0.39
TRPV1 Q8NER1 1/20 0.38
MEN1 O00255 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4257512 0.90 LMNA (0.48) FAAHNPC1RAB9ALMNATRPV1
SCHEMBL4265581 0.89 ALDH1A1 (0.42) MMP1MMP9MMP13ADAM17FAAH
SCHEMBL1086533 0.88 FAAH (0.55) FAAHMEN1CYP3A4CYP2D6KMT2A
SCHEMBL4257403 0.85 TSHR (0.45) POLBMEN1CYP3A4CYP2D6CYP2C9
SCHEMBL4262418 0.81 MEN1 (0.41) FAAHNPC1RAB9ALMNAMEN1
SCHEMBL4260775 0.80 PPIA (0.39) MMP13MCHR1MEN1CYP3A4CYP2D6
SCHEMBL4259750 0.79 TSHR (0.40) MCHR1TRPV1MEN1CYP3A4CYP2D6
SCHEMBL4265584 0.77 GRM2 (0.43) FAAHNPC1MEN1KMT2AGRM2
SCHEMBL1086743 0.76 MAPK1 (0.51) FAAHNPC1RAB9APOLBMEN1
SCHEMBL1086140 0.76 ALDH1A1 (0.51) MCHR1DRD4LMNAMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1910381-B1 SUBSTITUTED 1-OXA-3,8-DIAZASPIRO[4.5]-DECAN-2-ON- COMPOUNDS AND THE USE THEREOF FOR PRODUCING DRUGS GRUENENTHAL GMBH (DE) 2009-06-03 EP claimed
EP-1910381-A2 SUBSTITUTED 1-OXA-3,8-DIAZASPIRO[4.5]-DECAN-2-ON- COMPOUNDS AND THE USE THEREOF FOR PRODUCING DRUGS Grünenthal GmbH (DE) 2008-04-16 EP claimed
WO-2007000325-A2 SUBSTITUTED 1-OXA-3,8-DIAZASPIRO[4.5]-DECAN-2-ON- COMPOUNDS AND THE USE THEREOF FOR PRODUCING DRUGS Grünenthal GmbH (DE) 2007-01-04 WO claimed
EP-1910381-B1 SUBSTITUTED 1-OXA-3,8-DIAZASPIRO[4.5]-DECAN-2-ON- COMPOUNDS AND THE USE THEREOF FOR PRODUCING DRUGS GRUENENTHAL GMBH (DE) 2009-06-03 EP disclosed
EP-1910381-A2 SUBSTITUTED 1-OXA-3,8-DIAZASPIRO[4.5]-DECAN-2-ON- COMPOUNDS AND THE USE THEREOF FOR PRODUCING DRUGS Grünenthal GmbH (DE) 2008-04-16 EP disclosed
WO-2007000325-A2 SUBSTITUTED 1-OXA-3,8-DIAZASPIRO[4.5]-DECAN-2-ON- COMPOUNDS AND THE USE THEREOF FOR PRODUCING DRUGS Grünenthal GmbH (DE) 2007-01-04 WO disclosed