SCHEMBL4257750

SCHEMBL4257750

CCOC(=O)c1ccc(Oc2ccc(C(C)C)cc2)nc1

nearest known ligand 0.61

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
PDE4B Q07343 1/20 0.54
ACACB O00763 7/20 0.49
ACACA Q13085 5/20 0.49
NPC1 O15118 1/20 0.47
RAB9A P51151 1/20 0.47
L3MBTL1 Q9Y468 1/20 0.47
MAPT P10636 2/20 0.46
LMNA P02545 2/20 0.46
TSHR P16473 1/20 0.46
OXTR P30559 1/20 0.46
HRH3 Q9Y5N1 1/20 0.46
POLB P06746 1/20 0.44
PKM P14618 1/20 0.44
P2RX3 P56373 1/20 0.44
NPBWR1 P48145 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21656691 0.89 PDE4B (0.53) PDE4BACACBACACAL3MBTL1MAPT
SCHEMBL27837742 0.87 PDE4B (0.56) PDE4BRAB9AMAPTLMNATSHR
SCHEMBL19362950 0.87 PDE4B (0.58) PDE4BNPC1RAB9AL3MBTL1MAPT
SCHEMBL21656692 0.85 PDE4B (0.53) PDE4BACACBACACAMAPTLMNA
SCHEMBL21656686 0.85 LMNA (0.59) ACACBACACAL3MBTL1LMNAHRH3
SCHEMBL20482160 0.85 PDE4B (0.57) PDE4BRAB9AL3MBTL1MAPTLMNA
SCHEMBL6179875 0.85 PDE4B (0.57) PDE4BRAB9AL3MBTL1MAPTLMNA
SCHEMBL27549382 0.84 PDE4B (0.50) PDE4BACACBACACAL3MBTL1MAPT
SCHEMBL2767153 0.84 PDE4B (0.56) PDE4BL3MBTL1MAPTLMNATSHR
SCHEMBL2255952 0.84 PDE4B (0.56) PDE4BNPC1RAB9AL3MBTL1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12600696-B2 Aromatic compounds Xeniopro GmbH (DE) 2026-04-14 US disclosed
US-20230150923-A1 NOVEL AROMATIC COMPOUNDS Xeniopro GmbH (DE) 2023-05-18 US disclosed
US-11591289-B2 Aromatic compounds Xeniopro GmbH (DE) 2023-02-28 US disclosed
US-20210107863-A2 NOVEL AROMATIC COMPOUNDS Xeniopro GmbH (DE) 2021-04-15 US disclosed
US-20210107863-A2 NOVEL AROMATIC COMPOUNDS Xeniopro GmbH (DE) 2021-04-15 US disclosed
US-20200031763-A1 NOVEL AROMATIC COMPOUNDS Xeniopro GmbH (DE) 2020-01-30 US disclosed
US-20090239860-A1 NOVEL BENZOFURAN DERIVATIVE, MEDICINAL COMPOSITION CONTAINING THE SAME, AND USES OF THESE KISSEI PHARMACEUTICAL CO., LTD. (JP) 2009-09-24 US disclosed
EP-1710233-A1 NOVEL BENZOFURAN DERIVATIVE, MEDICINAL COMPOSITION CONTAINING THE SAME, AND USES OF THESE Kissei Pharmaceutical Co., Ltd. (JP) 2006-10-11 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090239860-A1 NOVEL BENZOFURAN DERIVATIVE, MEDICINAL COMPOSITION CONTAINING THE SAME, AND USES OF THESE ADORA2A, ADORA2B, HTR1F PDE4B 962/4885ACACB 1566/4885ACACA 1638/4885
US-20230150923-A1 NOVEL AROMATIC COMPOUNDS AHR, TYR, MUSK PDE4B 4605/4885ACACB 1264/4885ACACA 1539/4885
US-11591289-B2 Aromatic compounds AHR, TYR, MUSK PDE4B 4661/4885ACACB 1658/4885ACACA 2012/4885
US-20210107863-A2 NOVEL AROMATIC COMPOUNDS AHR, TYR, MUSK PDE4B 4605/4885ACACB 1264/4885ACACA 1539/4885
US-12600696-B2 Aromatic compounds CCR1, CCRL2, AHR PDE4B 4799/4885ACACB 120/4885ACACA 136/4885
US-20200031763-A1 NOVEL AROMATIC COMPOUNDS AHR, TYR, MUSK PDE4B 4605/4885ACACB 1264/4885ACACA 1539/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.