SCHEMBL4259750

SCHEMBL4259750

O=C(NCc1ccc(Cl)c(Cl)c1)ON1CCC2(CC1)CN(Cc1ccc3ccccc3c1)C(=O)O2

nearest known ligand 0.43

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
TSHR P16473 2/20 0.40
SSTR3 P32745 2/20 0.40
GRM2 Q14416 1/20 0.39
CCR3 P51677 1/20 0.38
MEN1 O00255 1/20 0.37
CYP3A4 P08684 1/20 0.37
CYP2D6 P10635 1/20 0.37
CYP2C9 P11712 1/20 0.37
KMT2A Q03164 1/20 0.37
TRPV1 Q8NER1 1/20 0.37
SMN1; SMN2 Q16637 1/20 0.37
ALDH1A1 P00352 1/20 0.37
HCRTR1 O43613 1/20 0.37
SIGMAR1 Q99720 1/20 0.36
MCHR1 Q99705 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4272713 0.88 TSHR (0.45) TSHRGRM2MEN1KMT2ASMN1; SMN2
SCHEMBL4271658 0.88 TSHR (0.39) TSHRGRM2MEN1CYP2C9KMT2A
SCHEMBL1086552 0.87 HRH3 (0.46) CCR3MEN1KMT2ATRPV1SMN1; SMN2
SCHEMBL4258569 0.79 MMP1 (0.43) GRM2MEN1CYP3A4CYP2D6CYP2C9
SCHEMBL4260775 0.77 PPIA (0.39) GRM2MEN1CYP3A4CYP2D6CYP2C9
SCHEMBL4259608 0.77 TP53 (0.39) GRM2ALDH1A1
SCHEMBL4265581 0.76 ALDH1A1 (0.42) TSHRMEN1KMT2AALDH1A1MCHR1
SCHEMBL5011798 0.76 TSHR (0.41) TSHRSSTR3CCR3MEN1CYP3A4
SCHEMBL1086756 0.75 CCR3 (0.42) GRM2CCR3
SCHEMBL1086470 0.75 FAAH (0.42) GRM2MEN1CYP3A4CYP2D6CYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1910381-B1 SUBSTITUTED 1-OXA-3,8-DIAZASPIRO[4.5]-DECAN-2-ON- COMPOUNDS AND THE USE THEREOF FOR PRODUCING DRUGS GRUENENTHAL GMBH (DE) 2009-06-03 EP claimed
EP-1910381-B1 SUBSTITUTED 1-OXA-3,8-DIAZASPIRO[4.5]-DECAN-2-ON- COMPOUNDS AND THE USE THEREOF FOR PRODUCING DRUGS GRUENENTHAL GMBH (DE) 2009-06-03 EP disclosed