Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 12/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.33 |
| ▸ | TOP2A | P11388 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | HSD11B2 | P80365 | 4/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | SCN1A | P35498 | 1/20 | 0.30 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.30 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4258533 | 0.76 | ALDH1A1 (0.36) | HSD11B1SCN9AALDH1A1L3MBTL1HSD11B2 | |
| SCHEMBL708623 | 0.76 | HSD11B1 (0.34) | HSD11B1SCN9AHSD11B2SCN1ASCN2A | |
| SCHEMBL1118091 | 0.74 | HSD11B1 (0.35) | HSD11B1SCN9AHSD11B2 | |
| SCHEMBL705638 | 0.70 | HSD11B1 (0.37) | HSD11B1SCN9AALDH1A1 | |
| SCHEMBL4089109 | 0.69 | HSD11B1 (0.39) | HSD11B1SCN9AALDH1A1HSD11B2KDM4E | |
| SCHEMBL15831171 | 0.69 | GLA (0.47) | HSD11B1SCN9AALDH1A1L3MBTL1MEN1 | |
| SCHEMBL328911 | 0.69 | HSD11B1 (0.49) | HSD11B1SCN9AALDH1A1HSD11B2SCN1A | |
| SCHEMBL1116549 | 0.69 | HSD11B1 (0.41) | HSD11B1ALDH1A1 | |
| SCHEMBL4088428 | 0.68 | HSD11B1 (0.39) | HSD11B1SCN9AHSD11B2 | |
| SCHEMBL75365 | 0.67 | HSD11B1 (0.45) | HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2104665-A2 | IMIDAZOLONE AND IMIDAZOLIDINONE DERIVATIVES AS 11B-HSD1 INHIBITORS FOR DIABETES | F. Hoffmann-Roche AG (CH) | 2009-09-30 | — | — | EP | disclosed |
| WO-2008046758-A2 | IMIDAZOLONE AND IMIDAZOLIDINONE DERIVATIVES AS 11B-HSD1 INHIBITORS FOR DIABETES | F. HOFFMANN-LA ROCHE AG (CH) | 2008-04-24 | — | — | WO | disclosed |