Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 10/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.35 |
| ▸ | SCN1A | P35498 | 1/20 | 0.32 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.32 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.32 |
| ▸ | HSD11B2 | P80365 | 3/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | GLA | P06280 | 1/20 | 0.30 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.30 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4261014 | 0.85 | HSD11B1 (0.36) | ALDH1A1HSD11B1HSD11B2POLB | |
| SCHEMBL74485 | 0.79 | HSD11B1 (0.41) | HSD11B1HSD11B2 | |
| SCHEMBL4260940 | 0.76 | HSD11B1 (0.33) | ALDH1A1L3MBTL1HSD11B1SCN9ASCN1A | |
| SCHEMBL4084557 | 0.75 | SCN9A (0.39) | ALDH1A1HSD11B1SCN9AHSD11B2 | |
| SCHEMBL4079305 | 0.75 | TOP2A (0.39) | ALDH1A1L3MBTL1HSD11B1SCN9AHSD11B2 | |
| SCHEMBL75228 | 0.75 | HSD11B1 (0.35) | HSD11B1 | |
| SCHEMBL75902 | 0.75 | HSD11B1 (0.39) | HSD11B1SCN9AHSD11B2 | |
| SCHEMBL4081955 | 0.75 | DGAT1 (0.37) | HSD11B1SCN9AHSD11B2 | |
| SCHEMBL4083851 | 0.74 | SCN9A (0.39) | HSD11B1SCN9AHSD11B2 | |
| SCHEMBL4083612 | 0.74 | SCN9A (0.39) | ALDH1A1HSD11B1SCN9AHSD11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2104665-A2 | IMIDAZOLONE AND IMIDAZOLIDINONE DERIVATIVES AS 11B-HSD1 INHIBITORS FOR DIABETES | F. Hoffmann-Roche AG (CH) | 2009-09-30 | — | — | EP | disclosed |
| WO-2008046758-A2 | IMIDAZOLONE AND IMIDAZOLIDINONE DERIVATIVES AS 11B-HSD1 INHIBITORS FOR DIABETES | F. HOFFMANN-LA ROCHE AG (CH) | 2008-04-24 | — | — | WO | disclosed |