Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.39 |
| ▸ | PRKCA | P17252 | 1/20 | 0.39 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 3/20 | 0.38 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | MLYCD | O95822 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
| ▸ | THRA | P10827 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13912551 | 0.95 | MAPT (0.40) | MAPTMEN1RECQLKMT2ALMNA | |
| SCHEMBL4268679 | 0.82 | MAPT (0.50) | MAPTMEN1RECQLKMT2ALMNA | |
| SCHEMBL5047248 | 0.79 | HDAC1 (0.43) | MAPTMEN1KMT2ALMNAHDAC1 | |
| SCHEMBL4268670 | 0.79 | LMNA (0.45) | MAPTMEN1KMT2ALMNAMAPK1 | |
| SCHEMBL4260612 | 0.73 | MAPT (0.48) | MAPTMEN1RECQLKMT2ALMNA | |
| SCHEMBL4232007 | 0.70 | NPSR1 (0.52) | MAPTMEN1RECQLKMT2ALMNA | |
| SCHEMBL14780442 | 0.69 | CES2 (0.56) | MAPTMEN1KMT2ALMNAMAPK1 | |
| SCHEMBL4261485 | 0.69 | LMNA (0.50) | MAPTLMNAMAPK1RAB9ANR4A2 | |
| SCHEMBL4262193 | 0.69 | MAPT (0.46) | MAPTMEN1RECQLKMT2ALMNA | |
| SCHEMBL7861710 | 0.69 | GSK3B (0.49) | MEN1KMT2AMAPK1ALDH1A1MMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1805159-A1 | SUBSTITUTED CARBOXYLIC ACIDS | The Institutes for Pharmaceutical Discovery, LLC (US) | 2007-07-11 | — | — | EP | claimed |
| WO-2006050212-A1 | SUBSTITUTED CARBOXYLIC ACIDS | THE INSTITUTES FOR PHARMACEUTICAL DISCOVERY LLC (US) | 2006-05-11 | — | — | WO | claimed |
| US-20060094747-A1 | Substituted carboxylic acids | THE INSTITUTE FOR PHARMACEUTICAL DISCOVERY, L.L.C. | 2006-05-04 | — | — | US | claimed |
| US-20090082392-A1 | Substituted Carboxylic Acids | THE INSTITUTES FOR PHARMACEUTICAL DISCOVERY LLC | 2009-03-26 | — | — | US | disclosed |
| US-7358364-B2 | treatment of diabetes and/or cancer; useful in the treatment of syndrome X; capable of inhibiting Protein tyrosine phosphatase | THE INSTITUTE FOR PHARMACEUTICAL DISCOVERY LLC (US) | 2008-04-15 | — | — | US | disclosed |
| EP-1805159-A1 | SUBSTITUTED CARBOXYLIC ACIDS | The Institutes for Pharmaceutical Discovery, LLC (US) | 2007-07-11 | — | — | EP | disclosed |
| WO-2006050212-A1 | SUBSTITUTED CARBOXYLIC ACIDS | THE INSTITUTES FOR PHARMACEUTICAL DISCOVERY LLC (US) | 2006-05-11 | — | — | WO | disclosed |
| US-20060094747-A1 | Substituted carboxylic acids | THE INSTITUTE FOR PHARMACEUTICAL DISCOVERY, L.L.C. | 2006-05-04 | — | — | US | disclosed |
| EP-1620420-A2 | SUBSTITUTED CARBOXYLIC ACIDS | The Institutes for Pharmaceutical Discovery, LLC (US) | 2006-02-01 | — | — | EP | disclosed |
| US-20040266788-A1 | Substituted carboxylic acids | THE INSTITUTE FOR PHARMACEUTICAL DISCOVERY LLC | 2004-12-30 | — | — | US | disclosed |
| WO-2004099168-A2 | SUBSTITUTED CARBOXYLIC ACIDS | THE INSTITUTES FOR PHARMACEUTICAL DISCOVERY, LLC (US) | 2004-11-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040266788-A1 | Substituted carboxylic acids | PTP4A1, PTPRS, G6PC1 | MAPT 1123/4885MEN1 2359/4885RECQL 3466/4885 |
| US-20060094747-A1 | Substituted carboxylic acids | PTPRS, PTPRO, PTPRJ | MAPT 1249/4885MEN1 2928/4885RECQL 3216/4885 |
| US-20090082392-A1 | Substituted Carboxylic Acids | PTPRJ, PTPRS, PTPRG | MAPT 1173/4885MEN1 3127/4885RECQL 3393/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.