SCHEMBL4263152

SCHEMBL4263152

COc1cc(C2CCCC2N)ccc1Cl

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM1A O60341 4/20 0.44
MAPK1 P28482 1/20 0.41
SMN1; SMN2 Q16637 1/20 0.41
HTR2A P28223 2/20 0.40
HTR1A P08908 1/20 0.40
HTR1D P28221 1/20 0.40
HTR1B P28222 1/20 0.40
HTR1E P28566 1/20 0.40
HTR7 P34969 1/20 0.40
HTR2B P41595 1/20 0.40
HTR3A P46098 1/20 0.40
HTR5A P47898 1/20 0.40
HTR6 P50406 1/20 0.40
TP53 P04637 2/20 0.40
PKM P14618 1/20 0.40
ALOX15 P16050 1/20 0.40
TUBB4A P04350 1/20 0.38
TUBB P07437 1/20 0.38
TUBA3C P0DPH7 1/20 0.38
TUBA1B P68363 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4260439 0.83 KDM1A (0.51) KDM1ATUBB4ATUBBTUBA3CTUBA1B
SCHEMBL1380700 0.83 KDM1A (0.51) KDM1ATUBB4ATUBBTUBA3CTUBA1B
SCHEMBL1380697 0.83 KDM1A (0.51) KDM1ATUBB4ATUBBTUBA3CTUBA1B
SCHEMBL2826447 0.83 KDM1A (0.51) KDM1ATUBB4ATUBBTUBA3CTUBA1B
SCHEMBL10192778 0.80 SLC6A2 (0.45)
SCHEMBL18423957 0.79 CYP2C9 (0.38) KDM1AMAPK1HTR2AHTR2BALDH1A1
SCHEMBL5334908 0.79 CA2 (0.51) KDM1AALDH1A1TSHR
SCHEMBL5334911 0.79 CA2 (0.51) KDM1AALDH1A1TSHR
SCHEMBL8333221 0.76 TUBB4A (0.43) KDM1AMAPK1SMN1; SMN2HTR2AHTR2B
SCHEMBL4259945 0.75 KDM1A (0.51) KDM1AMAPK1DPP4ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1833782-B1 CYCLOALKYLAMINE DERIVATIVES HOFFMANN LA ROCHE (CH) 2009-04-08 EP disclosed