Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 4/20 | 0.40 |
| ▸ | HTR6 | P50406 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
| ▸ | DAO | P14920 | 3/20 | 0.37 |
| ▸ | DDO | Q99489 | 2/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA7 | P43166 | 1/20 | 0.36 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.35 |
| ▸ | CNR1 | P21554 | 1/20 | 0.35 |
| ▸ | FEN1 | P39748 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27867018 | 0.78 | KDM4E (0.47) | CA2HTR6DAOKDM4EALDH1A1 | |
| SCHEMBL31561597 | 0.75 | CA2 (0.62) | CA2HTR6DAOCA12CA1 | |
| SCHEMBL3237494 | 0.75 | CA2 (0.62) | CA2HTR6DAOCA12CA1 | |
| SCHEMBL27462488 | 0.72 | HRH3 (0.44) | CA2HTR6DAOKDM4EAKR1B1 | |
| SCHEMBL17803693 | 0.72 | CA2 (0.42) | CA2HTR6CA1AKR1B1CNR1 | |
| SCHEMBL7407839 | 0.72 | CNR1 (0.54) | CA2HTR6AKR1B1CNR1 | |
| SCHEMBL6618503 | 0.72 | CA2 (0.46) | CA2HTR6KDM4EALDH1A1AKR1B1 | |
| SCHEMBL5190594 | 0.72 | AKR1B1 (0.56) | CA2HTR6DAOKDM4EALDH1A1 | |
| SCHEMBL8960443 | 0.72 | HTR6 (0.56) | CA2HTR6POLBGAAGFER | |
| SCHEMBL8120975 | 0.72 | KDM4E (0.49) | CA2HTR6POLBDAOCA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2091953-A1 | 8-SULFONYL-L, 3, 4, 8-TETRAHYDR0-2H- [1, 4]OXAZEPINO [6, 7-E]INDOLE DERIVATIVES AND THEIR USE AS 5-HT6 RECEPTOR LIGANDS | BIOVITRUM AB (publ) (SE) | 2009-08-26 | — | — | EP | disclosed |
| WO-2008054288-A1 | 8-SULFONYL-L, 3, 4, 8-TETRAHYDR0-2H- [1, 4] OXAZEPINO [6, 7-E] INDOLE DERIVATIVES AND THEIR USE AS 5-HT6 RECEPTOR LIGANDS | BIOVITRUM AB (PUBL) (SE) | 2008-05-08 | — | — | WO | disclosed |